发明授权
- 专利标题: Aminopyrazole derivative
- 专利标题(中): 氨基吡唑衍生物
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申请号: US13389146申请日: 2010-08-05
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公开(公告)号: US08829199B2公开(公告)日: 2014-09-09
- 发明人: Naoki Taka , Masayuki Ohmori , Kyoko Takami , Masayuki Matsushita , Tadakatsu Hayase , Ikumi Hyodo , Masami Kochi , Hiroki Nishii , Hirosato Ebiike , Yoshito Nakanishi , Toshiyuki Mio , Lisha Wang , Weili Zhao
- 申请人: Naoki Taka , Masayuki Ohmori , Kyoko Takami , Masayuki Matsushita , Tadakatsu Hayase , Ikumi Hyodo , Masami Kochi , Hiroki Nishii , Hirosato Ebiike , Yoshito Nakanishi , Toshiyuki Mio , Lisha Wang , Weili Zhao
- 申请人地址: JP Tokyo CH Basel
- 专利权人: Chugai Seiyaku Kabushiki Kaisha,F. Hoffmann-La Roche AG
- 当前专利权人: Chugai Seiyaku Kabushiki Kaisha,F. Hoffmann-La Roche AG
- 当前专利权人地址: JP Tokyo CH Basel
- 代理机构: Fish & Richardson P.C.
- 优先权: JP2009-184822 20090807
- 国际申请: PCT/JP2010/063315 WO 20100805
- 国际公布: WO2011/016528 WO 20110210
- 主分类号: A61K31/4184
- IPC分类号: A61K31/4184 ; C07D401/14 ; C07D403/14 ; C07D405/14 ; C07D413/14 ; C07D417/14 ; C07D471/04
摘要:
A compound represented by formula (I) or a pharmacologically acceptable salt thereof, which can inhibit a fibroblast growth factor receptor (FGFR) family kinase in cancer tissues. (In the formula, A represents a 5- to 10-membered heteroaryl group, or a C6-10 aryl group; R1 and R2 independently represent H, OH, X, CN, NO2, a C1-4 haloalkyl group, a C1-6 alkyl group, or the like ; R3 represents H, a C1-5 alkyl group, a C6-10 aryl group, a C1-5 alkyl group, or a C1-4 haloalkyl group; and R4 represents H, X, a C1-3 alkyl group, a C1-4 haloalkyl group, OH, CN, NO2, or the like.)
公开/授权文献
- US20120208811A1 Aminopyrazole Derivative 公开/授权日:2012-08-16
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