发明授权
- 专利标题： Thrombolytic enzyme and a process for its preparation
- 专利标题（中）： 溶血酶及其制备方法
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申请号： US11907512申请日： 2007-10-12
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公开(公告)号： US08835145B2公开(公告)日： 2014-09-16
- 发明人: Perurmadom Ramaiyer Mahadevan , Subrahamanyam Chivukula Sekar , Sundaramurthy Suresh Babu
- 申请人： Subrahamanyam Chivukula Sekar , Sundaramurthy Suresh Babu , Sita Mahadevan
- 申请人地址： IN New Delhi IN Chennai
- 专利权人： National Research Development Corporation,India and Malladi Drugs Pharmaceuticals Ltd.
- 当前专利权人： National Research Development Corporation,India and Malladi Drugs Pharmaceuticals Ltd.
- 当前专利权人地址： IN New Delhi IN Chennai
- 代理机构： Venable LLP
- 代理商 Keith G. Haddaway; Annette K. Kwok
- 主分类号： A61K38/43
- IPC分类号： A61K38/43 ; C12N1/20 ; C12N9/00 ; C12N9/54 ; C12N9/74 ; C12Q1/56 ; C12N9/64
摘要：
The invention relates to a thrombolytic enzyme referred to as Thrombinase having a molecular weight of 31,000 to 32,000. Such a thrombolytic enzyme can be used for dissolving blood clots. The process comprises culturing a filtrate of Bacillus sphaericus sero type H5a 5b, removing the cell, subjecting the cell supernatant to filtration, salting out the retentate, subjecting the precipitate to dialysis, reprecipitating the precipitate and then reconstituting in buffer and finally decolorizing, purifying and dialyzing.
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