发明授权
US08846655B2 4-substituted-2-phenoxy-phenylamine delta opioid receptor modulators
有权
4-取代-2-苯氧基 - 苯胺δ阿片样物质受体调节剂
- 专利标题: 4-substituted-2-phenoxy-phenylamine delta opioid receptor modulators
- 专利标题(中): 4-取代-2-苯氧基 - 苯胺δ阿片样物质受体调节剂
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申请号: US13503433申请日: 2010-10-28
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公开(公告)号: US08846655B2公开(公告)日: 2014-09-30
- 发明人: Steven J. Coats , Haiyan Bian , Chaozhong Cai , Bart L. DeCorte , Li Liu , Mark J. Macielag , Scott L. Dax , Philip M. Pitis , Peter J. Connolly , Wei He
- 申请人: Steven J. Coats , Haiyan Bian , Chaozhong Cai , Bart L. DeCorte , Li Liu , Mark J. Macielag , Scott L. Dax , Philip M. Pitis , Peter J. Connolly , Wei He
- 申请人地址: BE
- 专利权人: Janssen Pharmaceutica, NV
- 当前专利权人: Janssen Pharmaceutica, NV
- 当前专利权人地址: BE
- 国际申请: PCT/US2010/054497 WO 20101028
- 国际公布: WO2011/053706 WO 20110505
- 主分类号: A61K31/40
- IPC分类号: A61K31/40 ; A61K31/445 ; A61K31/4439 ; A61K31/4025 ; A61K31/506 ; A61K31/495 ; C07D211/56 ; C07D405/12 ; C07D207/09 ; C07C255/50 ; C07C211/48 ; C07D413/12 ; C07D401/12 ; C07C211/50 ; C07D205/04 ; C07C233/08 ; C07C233/11 ; C07C233/65 ; C07D451/04 ; C07D453/02 ; C07D409/12
摘要:
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, Ra, and Y are defined herein.