Invention Grant
- Patent Title: 1-oxyalkyl-2-carboxy-7-nonsubstituted indole derivatives
- Patent Title (中): 1-氧代烷基-2-羧基-7-非取代的吲哚衍生物
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Application No.: US13088206Application Date: 2011-04-15
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Publication No.: US08853209B2Publication Date: 2014-10-07
- Inventor: Xiaohong Song , Hong Ding , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Cheol-Min Park , Zhi-Fu Tao , Xilu Wang , Aaron R. Kunzer
- Applicant: Xiaohong Song , Hong Ding , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Cheol-Min Park , Zhi-Fu Tao , Xilu Wang , Aaron R. Kunzer
- Applicant Address: US IL North Chicago
- Assignee: AbbVie Inc.
- Current Assignee: AbbVie Inc.
- Current Assignee Address: US IL North Chicago
- Agency: Jones Day
- Main IPC: C07D209/42
- IPC: C07D209/42 ; C07D403/04
Abstract:
Compounds of Formula I wherein A1, B1, C1, D1, E1, F1 and L1 are as defined herein, which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mdl-1 protein, such as leukemia and lymphoma, are disclosed.
Public/Granted literature
- US20110263599A1 7-NONSUBSTITUTED INDOLE MCL-1 INHIBITORS Public/Granted day:2011-10-27
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