发明授权
- 专利标题： 1-oxyalkyl-2-carboxy-7-nonsubstituted indole derivatives
- 专利标题（中）： 1-氧代烷基-2-羧基-7-非取代的吲哚衍生物
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申请号： US13088206申请日： 2011-04-15
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公开(公告)号： US08853209B2公开(公告)日： 2014-10-07
- 发明人: Xiaohong Song , Hong Ding , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Cheol-Min Park , Zhi-Fu Tao , Xilu Wang , Aaron R. Kunzer
- 申请人： Xiaohong Song , Hong Ding , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Cheol-Min Park , Zhi-Fu Tao , Xilu Wang , Aaron R. Kunzer
- 申请人地址： US IL North Chicago
- 专利权人： AbbVie Inc.
- 当前专利权人： AbbVie Inc.
- 当前专利权人地址： US IL North Chicago
- 代理机构： Jones Day
- 主分类号： C07D209/42
- IPC分类号： C07D209/42 ; C07D403/04
摘要：
Compounds of Formula I wherein A1, B1, C1, D1, E1, F1 and L1 are as defined herein, which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mdl-1 protein, such as leukemia and lymphoma, are disclosed.
公开/授权文献
- US20110263599A1 7-NONSUBSTITUTED INDOLE MCL-1 INHIBITORS 公开/授权日：2011-10-27