Invention Grant
- Patent Title: Cycloalkylamines as monoamine reuptake inhibitors
- Patent Title (中): 环烷基胺作为单胺再摄取抑制剂
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Application No.: US12688474Application Date: 2010-01-15
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Publication No.: US08877975B2Publication Date: 2014-11-04
- Inventor: Liming Shao , Fengjiang Wang , Scott Christopher Malcolm , Michael Charles Hewitt , Larry R. Bush , Jianguo Ma , Mark A. Varney , Una Campbell , Sharon Rae Engel , Larry Wendell Hardy , Patrick Koch , John E. Campbell
- Applicant: Liming Shao , Fengjiang Wang , Scott Christopher Malcolm , Michael Charles Hewitt , Larry R. Bush , Jianguo Ma , Mark A. Varney , Una Campbell , Sharon Rae Engel , Larry Wendell Hardy , Patrick Koch , John E. Campbell
- Applicant Address: US MA Marlborough
- Assignee: Sunovion Pharmaceuticals Inc.
- Current Assignee: Sunovion Pharmaceuticals Inc.
- Current Assignee Address: US MA Marlborough
- Agency: Choate, Hall & Stewart LLP
- Agent Andrea L. C. Reid; Daniel A. Klein
- Main IPC: C07C211/17
- IPC: C07C211/17 ; A61K31/137 ; C07C211/29 ; C07C211/40 ; C07C215/42 ; C07C215/44 ; C07C217/52 ; C07C217/74 ; C07C323/32 ; C07D207/06 ; C07D207/08 ; C07D211/14 ; C07D265/14 ; C07D277/28 ; C07D295/06 ; C07D307/52 ; C07D317/58 ; C07D317/72 ; C07D319/06 ; C07D333/20 ; C07D491/056
Abstract:
The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.
Public/Granted literature
- US20100190861A1 CYCLOALKYLAMINES AS MONOAMINE REUPTAKE INHIBITORS Public/Granted day:2010-07-29
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