- 专利标题： Fc variants with altered binding to FcRn
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申请号： US12697939申请日： 2010-02-01
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公开(公告)号： US08883973B2公开(公告)日： 2014-11-11
- 发明人: Aaron Keith Chamberlain , Bassil I. Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
- 申请人： Aaron Keith Chamberlain , Bassil I. Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
- 申请人地址： US CA Monrovia
- 专利权人： Xencor, Inc.
- 当前专利权人： Xencor, Inc.
- 当前专利权人地址： US CA Monrovia
- 代理机构： Morgan, Lewis & Bockius, LLP
- 代理商 Gargi Talukder; Robin M. Silva
- 主分类号： C07K16/00
- IPC分类号： C07K16/00 ; C12P21/08 ; A61K39/395 ; A61K39/40 ; C07K16/22 ; C07K16/24 ; C07K16/08 ; C07K16/42 ; C07K16/28 ; C07K16/32 ; C07K1/00 ; A61K39/00
摘要：
The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.
公开/授权文献
- US20100234572A1 Fc Variants with altered binding to FcRn 公开/授权日：2010-09-16
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