发明授权
- 专利标题： Inhibitors of 11β-hydroxysteroid dehydrogenase type 1
- 专利标题（中）： 11＆bgr-羟基类固醇脱氢酶抑制剂1型
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申请号： US12310457申请日： 2007-08-24
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公开(公告)号： US08927715B2公开(公告)日： 2015-01-06
- 发明人: David A. Claremon , Suresh B. Singh , Colin M. Tice , Yuanjie Ye , Salvacion Cacatian , Wei He , Robert Simpson , Zhenrong Xu , Wei Zhao
- 申请人： David A. Claremon , Suresh B. Singh , Colin M. Tice , Yuanjie Ye , Salvacion Cacatian , Wei He , Robert Simpson , Zhenrong Xu , Wei Zhao
- 申请人地址： US PA Fort Washington
- 专利权人： Vitae Pharmaceuticals, Inc.
- 当前专利权人： Vitae Pharmaceuticals, Inc.
- 当前专利权人地址： US PA Fort Washington
- 代理机构： McCarter & English LLP
- 代理商 Steven G. Davis; Michael J. DeGrazia
- 国际申请： PCT/US2007/018789 WO 20070824
- 国际公布： WO2008/024497 WO 20080228
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; C07D471/10 ; A61K31/438 ; C07D221/20 ; C07D401/10 ; A61K31/496 ; C07D413/10 ; A61P3/00 ; A61P9/12 ; A61P9/00 ; A61P25/22 ; A61P25/28 ; A61P25/24 ; A61P15/08 ; C07D211/26 ; C07D413/06 ; C07D211/22 ; C07D491/107 ; C07D211/16 ; C07D211/34 ; C07D401/08 ; C07D401/06
摘要：
This invention relates to novel compounds of the Formula (I*), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.
公开/授权文献
- US20110034455A1 INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 公开/授权日：2011-02-10
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