Invention Grant
- Patent Title: Selective glycosidase inhibitors and uses thereof
- Patent Title (中): 选择性糖苷酶抑制剂及其用途
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Application No.: US13884061Application Date: 2011-11-08
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Publication No.: US08933040B2Publication Date: 2015-01-13
- Inventor: Craig A. Coburn , Kun Liu , Ernest J. McEacher , Changwei Mu , Harold G. Selnick , David J. Vocadlo , Yaode Wang , Zhongyong Wei , Yuanxi Zhou
- Applicant: Craig A. Coburn , Kun Liu , Ernest J. McEacher , Changwei Mu , Harold G. Selnick , David J. Vocadlo , Yaode Wang , Zhongyong Wei , Yuanxi Zhou
- Agency: Clark & Elbing LLP
- International Application: PCT/CA2011/001241 WO 20111108
- International Announcement: WO2012/061927 WO 20120518
- Main IPC: C08B37/00
- IPC: C08B37/00 ; C07D487/02 ; A61K31/70 ; A61K31/425 ; C07D513/14 ; C07D513/04 ; C07H9/06 ; C07H13/04 ; C07H13/12 ; C07H15/18 ; C12Q1/48
Abstract:
The invention provides compounds for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
Public/Granted literature
- US20140213584A9 SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF Public/Granted day:2014-07-31
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