发明授权
- 专利标题： Selective glycosidase inhibitors and uses thereof
- 专利标题（中）： 选择性糖苷酶抑制剂及其用途
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申请号： US13884061申请日： 2011-11-08
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公开(公告)号： US08933040B2公开(公告)日： 2015-01-13
- 发明人: Craig A. Coburn , Kun Liu , Ernest J. McEacher , Changwei Mu , Harold G. Selnick , David J. Vocadlo , Yaode Wang , Zhongyong Wei , Yuanxi Zhou
- 申请人： Craig A. Coburn , Kun Liu , Ernest J. McEacher , Changwei Mu , Harold G. Selnick , David J. Vocadlo , Yaode Wang , Zhongyong Wei , Yuanxi Zhou
- 代理机构： Clark & Elbing LLP
- 国际申请： PCT/CA2011/001241 WO 20111108
- 国际公布： WO2012/061927 WO 20120518
- 主分类号： C08B37/00
- IPC分类号： C08B37/00 ; C07D487/02 ; A61K31/70 ; A61K31/425 ; C07D513/14 ; C07D513/04 ; C07H9/06 ; C07H13/04 ; C07H13/12 ; C07H15/18 ; C12Q1/48
摘要：
The invention provides compounds for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
公开/授权文献
- US20140213584A9 SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF 公开/授权日：2014-07-31
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