发明授权
US08940722B2 Compounds for modulation of orphan nuclear receptor RAR-related orphan receptor-gamma (RORγ, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune disease
有权
用于调节孤儿核受体RAR相关孤儿受体γ（RORγ，NR1F3）活性和治疗慢性炎症和自身免疫疾病的化合物
- 专利标题： Compounds for modulation of orphan nuclear receptor RAR-related orphan receptor-gamma (RORγ, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune disease
- 专利标题（中）： 用于调节孤儿核受体RAR相关孤儿受体γ（RORγ，NR1F3）活性和治疗慢性炎症和自身免疫疾病的化合物
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申请号： US13581961申请日： 2011-02-28
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公开(公告)号： US08940722B2公开(公告)日： 2015-01-27
- 发明人: Olaf Kinzel , Christoph Steeneck , Gerald Kleymann , Michael Albers , Thomas Hoffmann , Claus Kremoser , Sanja Perovic-Ottstadt , Thomas Schlüter
- 申请人： Olaf Kinzel , Christoph Steeneck , Gerald Kleymann , Michael Albers , Thomas Hoffmann , Claus Kremoser , Sanja Perovic-Ottstadt , Thomas Schlüter
- 申请人地址： DE Ludwigshafen
- 专利权人： Phenex Pharmaceuticals AG
- 当前专利权人： Phenex Pharmaceuticals AG
- 当前专利权人地址： DE Ludwigshafen
- 代理机构： Seed IP Law Group PLLC
- 优先权： EP10002069 20100301
- 国际申请： PCT/EP2011/000976 WO 20110228
- 国际公布： WO2011/107248 WO 20110909
- 主分类号： C07D245/06
- IPC分类号： C07D245/06 ; C07D267/22 ; C07D413/10 ; C07D413/12 ; C07D417/12 ; C07D487/04 ; C07D498/04 ; A61K31/395 ; C07D281/18 ; C07D403/12
摘要：
The invention provides modulators for the orphan nuclear receptor RORγ and methods for treating RORγ mediated diseases by administrating these novel RORγ modulators to a human or a mammal in need thereof. Specifically, the present invention provides compounds of Formula (1) and the enantiomers, diastereomers, tautomers, solvates and pharmaceutically acceptable salts thereof.
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