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1.发明授权Compounds for modulation of orphan nuclear receptor RAR-related orphan receptor-gamma (RORγ, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune disease 有权用于调节孤儿核受体RAR相关孤儿受体γ（RORγ，NR1F3）活性和治疗慢性炎症和自身免疫疾病的化合物公开(公告)号：US08940722B2
公开(公告)日：2015-01-27
申请号：US13581961
申请日：2011-02-28
申请人： Olaf Kinzel , Christoph Steeneck , Gerald Kleymann , Michael Albers , Thomas Hoffmann , Claus Kremoser , Sanja Perovic-Ottstadt , Thomas Schlüter
发明人： Olaf Kinzel , Christoph Steeneck , Gerald Kleymann , Michael Albers , Thomas Hoffmann , Claus Kremoser , Sanja Perovic-Ottstadt , Thomas Schlüter
IPC分类号： C07D245/06 , C07D267/22 , C07D413/10 , C07D413/12 , C07D417/12 , C07D487/04 , C07D498/04 , A61K31/395 , C07D281/18 , C07D403/12
CPC分类号： C07D267/22 , C07D245/06 , C07D281/18 , C07D403/12 , C07D413/10 , C07D413/12 , C07D417/12 , C07D487/04 , C07D498/04
摘要： The invention provides modulators for the orphan nuclear receptor RORγ and methods for treating RORγ mediated diseases by administrating these novel RORγ modulators to a human or a mammal in need thereof. Specifically, the present invention provides compounds of Formula (1) and the enantiomers, diastereomers, tautomers, solvates and pharmaceutically acceptable salts thereof.
摘要翻译： 本发明提供了用于孤儿核受体RORγ的调节剂和通过将这些新的RORγ调节剂施用于有需要的人或哺乳动物来治疗RORγ介导的疾病的方法。 具体地说，本发明提供式（1）的化合物及其对映异构体，非对映异构体，互变异构体，溶剂合物及其药学上可接受的盐。
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2.发明授权Pyrrolo sulfonamide compounds for modulation of orphan nuclear receptor RAR-related orphan receptor-γ (ROR-γ, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune diseases 有权用于调节孤儿核受体RAR相关孤儿受体γ（ROR-γ，NR1F3）活性和治疗慢性炎症和自身免疫疾病的吡咯磺酰胺化合物公开(公告)号：US08946446B2
公开(公告)日：2015-02-03
申请号：US14110702
申请日：2012-04-13
IPC分类号： C07D209/02 , C07D207/00 , C07D215/00 , C07D401/00 , C07D413/00 , A61K31/44 , A61K31/535 , A61K31/397 , A61K31/445 , A61K31/40 , C07D209/30 , C07D207/36 , C07D401/04 , C07D403/04 , C07D403/10
CPC分类号： C07D209/30 , C07D207/36 , C07D401/04 , C07D403/04 , C07D403/10
摘要： The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administrating these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present invention provides pyrrolo sulfonamide compounds of Formula (1) and the enantiomers, diastereomers, tautomers, solvates and pharmaceutically acceptable salts thereof.
摘要翻译： 本发明提供了用于孤儿核受体RORy的调节剂和通过将这些新型RORY调节剂施用于有需要的人或哺乳动物来治疗RORy介导的疾病的方法。 具体地说，本发明提供式（1）的吡咯磺酰胺化合物及其对映异构体，非对映异构体，互变异构体，溶剂合物及其药学上可接受的盐。
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3.发明申请PYRROLO SULFONAMIDE COMPOUNDS FOR MODULATION OF ORPHAN NUCLEAR RECEPTOR RAR-RELATED ORPHAN RECEPTOR-GAMMA (ROR-GAMMA, NR1F3) ACTIVITY AND FOR THE TREATMENT OF CHRONIC INFLAMMATORY AND AUTOIMMUNE DISEASES 有权用于调节ORFAN核受体RAR相关ORFAN受体 - 游离（ROR-GAMMA，NR1F3）活性和用于治疗慢性炎症和自身免疫疾病的吡罗莫磺酰胺化合物公开(公告)号：US20140142082A1
公开(公告)日：2014-05-22
申请号：US14110702
申请日：2012-04-13
IPC分类号： C07D403/04 , C07D401/04 , C07D209/30 , C07D207/36
CPC分类号： C07D209/30 , C07D207/36 , C07D401/04 , C07D403/04 , C07D403/10
摘要： The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administrating these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present invention provides pyrrolo sulfonamide compounds of Formula (1) and the enantiomers, diastereomers, tautomers, solvates and pharmaceutically acceptable salts thereof.
摘要翻译： 本发明提供了用于孤儿核受体RORy的调节剂和通过将这些新型RORY调节剂施用于有需要的人或哺乳动物来治疗RORy介导的疾病的方法。 具体地说，本发明提供式（1）的吡咯磺酰胺化合物及其对映异构体，非对映异构体，互变异构体，溶剂合物及其药学上可接受的盐。
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4.发明授权2-(3-phenyl-2-piperazinyl-3,4-dihydroquinazolin-4-yl)acetic acids as antiviral agents, especially against cytomegaloviruses 有权2-（3-苯基-2-哌嗪基-3,4-二氢喹唑啉-4-基）乙酸作为抗病毒剂，特别是针对巨细胞病毒公开(公告)号：US07960387B2
公开(公告)日：2011-06-14
申请号：US10545453
申请日：2004-01-29
申请人： Tobias Wunberg , Judith Baumeister , Ulrich Betz , Mario Jeske , Gerald Kleymann , Thomas Lampe , Susanne Nikolic , Jürgen Reefschläger , Rudolf Schohe-Loop , Frank Süβmeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Jörg Keldenich , Thomas Krämer , Peter Nell , Tse-I Lin
发明人： Tobias Wunberg , Judith Baumeister , Ulrich Betz , Mario Jeske , Gerald Kleymann , Thomas Lampe , Susanne Nikolic , Jürgen Reefschläger , Rudolf Schohe-Loop , Frank Süβmeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Jörg Keldenich , Thomas Krämer , Peter Nell , Tse-I Lin
IPC分类号： A61K31/497 , A61P31/12 , C07D401/04 , C07D239/84
CPC分类号： C07D239/84
摘要： The invention relates to dihydroquinazolines and methods for the production thereof, the use thereof in the treatment and/or prophylaxis of diseases, in addition to the use thereof in the production of medicaments in the treatment and/or prophylaxis of diseases, especially for use as anti-viral agents, especially against cytomegalo viruses.
摘要翻译： 本发明涉及二氢喹唑啉及其制备方法，其用于治疗和/或预防疾病的用途，除了在制备药物中用于治疗和/或预防疾病，特别是用作 抗病毒剂，特别是针对巨细胞病毒。
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公开(公告)号：US07105553B2
公开(公告)日：2006-09-12
申请号：US10168197
申请日：2000-12-12
申请人： Rüdiger Fischer , Gerald Kleymann , Ulrich Betz , Judith Baumeister , Wolfgang Bender , Peter Eckenberg , Gabriele Handke , Martin Hendrix , Kerstin Henninger , Axel Jensen , Jörg Keldenich , Udo Schneider , Olaf Weber
发明人： Rüdiger Fischer , Gerald Kleymann , Ulrich Betz , Judith Baumeister , Wolfgang Bender , Peter Eckenberg , Gabriele Handke , Martin Hendrix , Kerstin Henninger , Axel Jensen , Jörg Keldenich , Udo Schneider , Olaf Weber
IPC分类号： A61K31/426 , C07D277/54
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/54 , C07D417/12 , C07F7/1804 , C07F9/6539
摘要： The present invention relates to novel compounds, to a process for their preparation and to their use as medicaments, in particular as antiviral medicaments.
摘要翻译： 本发明涉及新化合物，其制备方法及其用作药物，特别是抗病毒药物。
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公开(公告)号：US07883713B2
公开(公告)日：2011-02-08
申请号：US10481680
申请日：2002-06-10
申请人： Ulrich Betz , Tobias Laich , Wolfgang Bender , Ruediger Fischer , Martin Hendrix , Gerald Kleymann
发明人： Ulrich Betz , Tobias Laich , Wolfgang Bender , Ruediger Fischer , Martin Hendrix , Gerald Kleymann
CPC分类号： A61K31/427 , A61K9/0014 , A61K9/0048 , A61K31/426 , A61K47/06 , A61K47/10 , A61K47/32 , A61K47/34
摘要： The invention relates to the topical application of substituted thiazolyl amides in the treatment of herpes infections in humans, to preparations suitable for the topical application and to the production thereof.
摘要翻译： 本发明涉及取代的噻唑基酰胺在治疗人类疱疹感染中的局部应用，适用于局部应用的制剂及其制备。
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公开(公告)号：US20070004735A1
公开(公告)日：2007-01-04
申请号：US10541886
申请日：2003-12-24
申请人： Ulrich Betz , Guy Hewlett , Gerald Kleymann , Thomas Lampe , Tse-I Lin , Susanne Nikolic , Jurgen Reefshlager , Tobias Wunberg , Holger Zimmerman , Franz Zumpe , Wolfgang Bender , Kerstin Henninger , Axel Jensen , Jorg Keldenich , Rudolf Schohe-Loop
发明人： Ulrich Betz , Guy Hewlett , Gerald Kleymann , Thomas Lampe , Tse-I Lin , Susanne Nikolic , Jurgen Reefshlager , Tobias Wunberg , Holger Zimmerman , Franz Zumpe , Wolfgang Bender , Kerstin Henninger , Axel Jensen , Jorg Keldenich , Rudolf Schohe-Loop
IPC分类号： C12Q1/70 , A61K31/50 , A61K31/17 , C07C271/28
CPC分类号： C07C311/08 , C07C275/40 , C07D237/04 , G01N33/56994 , G01N2500/00
摘要： The invention relates to a method for inhibiting the replication of herpesviruses, to methods for identifying compounds which inhibit the replication of herpesviruses using this method, to compounds having activity against herpesviruses, to methods for their preparation and to their use for producing medicaments for the treatment of herpes infections.
摘要翻译： 本发明涉及一种抑制疱疹病毒复制的方法，用于鉴定使用该方法抑制疱疹病毒复制的化合物的方法，具有抗疱疹病毒活性的化合物，其制备方法及其用于制备治疗药物的用途 的疱疹感染。
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公开(公告)号：US06500817B1
公开(公告)日：2002-12-31
申请号：US09914554
申请日：2001-08-31
申请人： Rüdiger Fischer , Gerald Kleymann , Judith Baumeister , Wolfgang Bender , Ulrich Betz , Peter Eckenberg , Gabriele Handke , Martin Hendrix , Udo Schneider , Olaf Weber , Kerstin Henninger , Axel Jensen , Jörg Keldenich
发明人： Rüdiger Fischer , Gerald Kleymann , Judith Baumeister , Wolfgang Bender , Ulrich Betz , Peter Eckenberg , Gabriele Handke , Martin Hendrix , Udo Schneider , Olaf Weber , Kerstin Henninger , Axel Jensen , Jörg Keldenich
IPC分类号： A61K31426
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/54 , C07D417/12 , C07D487/04
摘要： The present invention relates to thiazolylurea derivatives, a process for their preparation, and their use as pharmaceuticals, in particular as antiviral pharmaceuticals.
摘要翻译： 本发明涉及噻唑基脲衍生物，其制备方法及其作为药物，特别是作为抗病毒药物的用途。
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9.发明申请2-(3-Phenyl-2-piperazinyl-3,4-dihydroquinazolin-4-yl)acetic acids as antiviral agents, especially against cytomegaloviruses 有权2-（3-苯基-2-哌嗪基-3,4-二氢喹唑啉-4-基）乙酸作为抗病毒剂，特别是针对巨细胞病毒公开(公告)号：US20070066622A1
公开(公告)日：2007-03-22
申请号：US10545453
申请日：2004-01-29
申请人： Tobias Wunberg , Judith Baumeister , Ulrich Betz , Mario Jeske , Gerald Kleymann , Thomas Lampe , Susanne Nikolic , Jurgen Reefshlager , Rudolf Schohe-Loop , Frank Submeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Jorg Keldenich , Thomas Kramer , Peter Nell , Tse-I Lin
发明人： Tobias Wunberg , Judith Baumeister , Ulrich Betz , Mario Jeske , Gerald Kleymann , Thomas Lampe , Susanne Nikolic , Jurgen Reefshlager , Rudolf Schohe-Loop , Frank Submeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Jorg Keldenich , Thomas Kramer , Peter Nell , Tse-I Lin
IPC分类号： A61K31/517 , C07D405/14 , C07D403/02
CPC分类号： C07D239/84
摘要： The invention relates to dihydroquinazolines and methods for the production thereof, the use thereof in the treatment and/or prophylaxis of diseases, in addition to the use thereof in the production of medicaments in the treatment and/or prophylaxis of diseases, especially for use as anti-viral agents, especially against cytomegalo viruses.
摘要翻译： 本发明涉及二氢喹唑啉及其制备方法，其用于治疗和/或预防疾病的用途，除了在制备药物中用于治疗和/或预防疾病，特别是用作 抗病毒剂，特别是针对巨细胞病毒。
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公开(公告)号：US20050059658A1
公开(公告)日：2005-03-17
申请号：US10482520
申请日：2002-06-17
申请人： Tobias Wunberg , Ulrich Betz , Sabine Hallenberger , Gerald Kleymann , Thomas Lampe , Susanne Nikolic , Jurgen Reefschlager , Franz Zumpe , Marcus Bauser , Wolfgang Bender , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Axel Jensen , Jorg Keldenich , Holger Zimmermann
发明人： Tobias Wunberg , Ulrich Betz , Sabine Hallenberger , Gerald Kleymann , Thomas Lampe , Susanne Nikolic , Jurgen Reefschlager , Franz Zumpe , Marcus Bauser , Wolfgang Bender , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Axel Jensen , Jorg Keldenich , Holger Zimmermann
IPC分类号： A61K31/50 , A61K31/501 , A61P31/12 , C07D237/04 , C07D237/32 , C07D417/12
CPC分类号： C07D417/12 , C07D237/04 , C07D237/32
摘要： The invention relates to novel compounds, to a method for the production of said compounds and to the use thereof as medicaments, more particularly as antiviral agents, especially against cytomegalovirus.
摘要翻译： 本发明涉及新化合物，所述化合物的制备方法及其作为药物的用途，更特别地涉及抗病毒剂，特别是抗巨细胞病毒。
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