发明授权
- 专利标题: Optical determination of glucose utilizing boronic acid adducts
- 专利标题(中): 使用硼酸加合物光学测定葡萄糖
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申请号: US12189094申请日: 2008-08-08
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公开(公告)号: US08951503B2公开(公告)日: 2015-02-10
- 发明人: Bakthan Singaram , Ritchie A. Wessling
- 申请人: Bakthan Singaram , Ritchie A. Wessling
- 申请人地址: US CA Oakland
- 专利权人: The Regents of the University of California
- 当前专利权人: The Regents of the University of California
- 当前专利权人地址: US CA Oakland
- 代理机构: TechLaw LLP
- 代理商 Sam K. Tahmassebi
- 主分类号: A61B10/00
- IPC分类号: A61B10/00 ; A61B8/00 ; A61B5/00 ; A61K49/00 ; B82Y5/00 ; B82Y10/00 ; B82Y15/00 ; B82Y30/00 ; C07D213/82 ; C07F5/02 ; C09K9/02 ; G01N33/542 ; G01N33/543 ; G01N33/58 ; G01N33/66
摘要:
The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. The range of detection is between about 400 and 800 nm. In particular, a sensory devise is implemented in a mammal to determine sugar levels. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.