Systems and methods for detecting Input/Output (I/O) device connection are described herein. The method includes physically coupling an I/O device to a host port through a first signal line and a second signal line. The method also includes driving the first signal line or the second signal line high via an active buffer of the I/O device. The method also includes providing an acknowledgement signal from the host to the device through the other signal line that is not being driven high by the active buffer of the I/O device.