Invention Grant
US08980281B2 High-yield transgenic mammalian expression system for generating virus-like particles
有权
用于产生病毒样颗粒的高产量转基因哺乳动物表达系统
- Patent Title: High-yield transgenic mammalian expression system for generating virus-like particles
- Patent Title (中): 用于产生病毒样颗粒的高产量转基因哺乳动物表达系统
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Application No.: US12704928Application Date: 2010-02-12
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Publication No.: US08980281B2Publication Date: 2015-03-17
- Inventor: Pei-Wen Hsiao , Chia-Ying Wu , Yi-Chun Yeh
- Applicant: Pei-Wen Hsiao , Chia-Ying Wu , Yi-Chun Yeh
- Applicant Address: TW Taipei
- Assignee: Academia Sinica
- Current Assignee: Academia Sinica
- Current Assignee Address: TW Taipei
- Agency: Panitch Schwarze Belisario & Nadel LLP
- Main IPC: A61K39/42
- IPC: A61K39/42 ; C12P21/00 ; C12N9/26 ; C07K16/08 ; C12N5/07 ; C12N15/00 ; A61P31/16 ; A61K39/215 ; A61K39/145 ; C07K14/005 ; A61K39/00
Abstract:
Virus-like particles (VLPs) of mammalian-hosted viruses, such as SARS-CoV and influenza viruses, have been recombinantly produced from Vero cells. The VLPs closely emulate the exterior of authentic virus particles and are highly immunogenic. They can elicit not only humoral but also cellular immune responses in a mammal. Compositions and methods related to the VLPs are also described.
Public/Granted literature
- US20100166769A1 High-yield Transgenic Mammalian Expression System for Generating Virus-like Particles Public/Granted day:2010-07-01
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