发明授权
US08980583B2 Cells deficient in CMP-N-acetylneuraminic acid hydroxylase and/or glycoprotein alpha-1,3-galactosyltransferase
有权
缺乏CMP-N-乙酰神经氨酸羟化酶和/或糖蛋白α-1,3-半乳糖基转移酶的细胞
- 专利标题： Cells deficient in CMP-N-acetylneuraminic acid hydroxylase and/or glycoprotein alpha-1,3-galactosyltransferase
- 专利标题（中）： 缺乏CMP-N-乙酰神经氨酸羟化酶和/或糖蛋白α-1,3-半乳糖基转移酶的细胞
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申请号： US13538825申请日： 2012-06-29
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公开(公告)号： US08980583B2公开(公告)日： 2015-03-17
- 发明人: Nan Lin , Henry J. George , Joaquina Mascarenhas , Trevor N. Collingwood , Kevin J. Kayser , Katherine Achtien
- 申请人： Nan Lin , Henry J. George , Joaquina Mascarenhas , Trevor N. Collingwood , Kevin J. Kayser , Katherine Achtien
- 申请人地址： US MO St. Louis
- 专利权人： Sigma-Aldrich Co. LLC
- 当前专利权人： Sigma-Aldrich Co. LLC
- 当前专利权人地址： US MO St. Louis
- 代理机构： Polsinelli PC
- 主分类号： C12N5/10
- IPC分类号： C12N5/10 ; C12N9/02 ; C12P21/00 ; C12N9/10
摘要：
The present invention provides non-human mammalian cell lines that are deficient in CMP-Neu5Ac hydroxylase (Cmah) and/or glycoprotein alpha-1,3-galactosyltransferase (Ggta1). Also provided are methods for using the cells disclosed herein for producing recombinant proteins with human-like patterns of glycosylation.
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