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1.发明授权Cells deficient in CMP-N-acetylneuraminic acid hydroxylase and/or glycoprotein alpha-1,3-galactosyltransferase 有权缺乏CMP-N-乙酰神经氨酸羟化酶和/或糖蛋白α-1,3-半乳糖基转移酶的细胞公开(公告)号：US08980583B2
公开(公告)日：2015-03-17
申请号：US13538825
申请日：2012-06-29
申请人： Nan Lin , Henry J. George , Joaquina Mascarenhas , Trevor N. Collingwood , Kevin J. Kayser , Katherine Achtien
发明人： Nan Lin , Henry J. George , Joaquina Mascarenhas , Trevor N. Collingwood , Kevin J. Kayser , Katherine Achtien
CPC分类号： C12P21/005 , C12N9/0071 , C12N9/1051 , C12N2510/00 , C12N2510/02 , C12N2510/04 , C12Y114/18002
摘要： The present invention provides non-human mammalian cell lines that are deficient in CMP-Neu5Ac hydroxylase (Cmah) and/or glycoprotein alpha-1,3-galactosyltransferase (Ggta1). Also provided are methods for using the cells disclosed herein for producing recombinant proteins with human-like patterns of glycosylation.
摘要翻译： 本发明提供缺乏CMP-Neu5Ac羟化酶（Cmah）和/或糖蛋白α-1,3-半乳糖基转移酶（Ggta1）的非人哺乳动物细胞系。 还提供了使用本文公开的细胞来生产具有人类糖基化模式的重组蛋白质的方法。
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2.发明申请CELLS DEFICIENT IN CMP-N-ACETYLNEURAMINIC ACID HYDROXYLASE AND/OR GLYCOPROTEIN ALPHA-1,3-GALACTOSYLTRANSFERASE 审中-公开CMP- N-乙酰氨基酸羟化酶和/或谷氨酰胺ALPHA-1,3-糖蛋白酶的细胞缺失公开(公告)号：US20150152463A1
公开(公告)日：2015-06-04
申请号：US14609603
申请日：2015-01-30
申请人： Nan Lin , Henry J. George , Joaquina Mascarenhas , Trevor N. Collingwood , Kevin J. Kayser , Katherine Achtien
发明人： Nan Lin , Henry J. George , Joaquina Mascarenhas , Trevor N. Collingwood , Kevin J. Kayser , Katherine Achtien
IPC分类号： C12P21/00
CPC分类号： C12P21/005 , C12N9/0071 , C12N9/1051 , C12N2510/00 , C12N2510/02 , C12N2510/04 , C12Y114/18002
摘要： The present invention provides non-human mammalian cell lines that are deficient in CMP-Neu5Ac hydroxylase (Cmah) and/or glycoprotein alpha-1,3-galactosyltransferase (Ggta1). Also provided are methods for using the cells disclosed herein for producing recombinant proteins with human-like patterns of glycosylation.
摘要翻译： 本发明提供缺乏CMP-Neu5Ac羟化酶（Cmah）和/或糖蛋白α-1,3-半乳糖基转移酶（Ggta1）的非人哺乳动物细胞系。 还提供了使用本文公开的细胞来生产具有人类糖基化模式的重组蛋白质的方法。
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3.发明授权Method of producing human-like glycosylation pattern using cells deficient in glutamine synthase, CMP-N-acetylneuraminic acid hydroxylase and/or glycoprotein alpha-1,3-galactosyltransferase 有权使用缺乏谷氨酰胺合成酶，CMP-N-乙酰神经氨酸羟化酶和/或糖蛋白α-1,3-半乳糖基转移酶的细胞产生人样糖基化模式的方法公开(公告)号：US09062338B1
公开(公告)日：2015-06-23
申请号：US14609603
申请日：2015-01-30
申请人： Nan Lin , Henry J. George , Joaquina Mascarenhas , Trevor N. Collingwood , Kevin J. Kayser , Katherine Achtien
发明人： Nan Lin , Henry J. George , Joaquina Mascarenhas , Trevor N. Collingwood , Kevin J. Kayser , Katherine Achtien
IPC分类号： C12P21/00
CPC分类号： C12P21/005 , C12N9/0071 , C12N9/1051 , C12N2510/00 , C12N2510/02 , C12N2510/04 , C12Y114/18002
摘要： The present invention provides non-human mammalian cell lines that are deficient in CMP-Neu5Ac hydroxylase (Cmah) and/or glycoprotein alpha-1,3-galactosyltransferase (Ggta1). Also provided are methods for using the cells disclosed herein for producing recombinant proteins with human-like patterns of glycosylation.
摘要翻译： 本发明提供缺乏CMP-Neu5Ac羟化酶（Cmah）和/或糖蛋白α-1,3-半乳糖基转移酶（Ggta1）的非人哺乳动物细胞系。 还提供了使用本文公开的细胞来生产具有人类糖基化模式的重组蛋白质的方法。
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公开(公告)号：US20130004992A1
公开(公告)日：2013-01-03
申请号：US13538825
申请日：2012-06-29
申请人： Nan Lin , Henry J. George , Joaquina Mascarenhas , Trevor N. Collingwood , Kevin J. Kayser , Katherine Achtien
发明人： Nan Lin , Henry J. George , Joaquina Mascarenhas , Trevor N. Collingwood , Kevin J. Kayser , Katherine Achtien
CPC分类号： C12P21/005 , C12N9/0071 , C12N9/1051 , C12N2510/00 , C12N2510/02 , C12N2510/04 , C12Y114/18002
摘要： The present invention provides non-human mammalian cell lines that are deficient in CMP-Neu5Ac hydroxylase (Cmah) and/or glycoprotein alpha-1,3-galactosyltransferase (Ggta1). Also provided are methods for using the cells disclosed herein for producing recombinant proteins with human-like patterns of glycosylation.
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