Invention Grant
- Patent Title: Antagonist antibodies against GDF-8 and uses therefor
- Patent Title (中): 抗GDF-8的抗体抗体，并用于此
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Application No.: US13916379Application Date: 2013-06-12
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Publication No.: US08992913B2Publication Date: 2015-03-31
- Inventor: Michelle M. Mader , James R. Apgar , Kevin D. Parris
- Applicant: Pfizer Inc.
- Applicant Address: US NY New York
- Assignee: Pfizer Inc.
- Current Assignee: Pfizer Inc.
- Current Assignee Address: US NY New York
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/395 ; C07K16/00 ; C07K16/18 ; C07K16/22 ; C12N15/11 ; C12N15/12 ; C12N15/13
Abstract:
The disclosure provides improved neutralizing anti-GDF-8 antibodies capable of substantially higher levels of expression in host cells compared to previous anti-GDF-8 antibodies. Also provided are methods of using compositions comprising such antibodies to increase muscle mass or strength, and to treat or prevent muscular disorders, neuromuscular disorders, metabolic disorders, adipose tissue disorders or bone disorders.
Public/Granted literature
- US20130336982A1 ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES THEREFOR Public/Granted day:2013-12-19
Information query
