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公开(公告)号：US10550200B2
公开(公告)日：2020-02-04
申请号：US15239556
申请日：2016-08-17
Applicant: Pfizer Inc.
Inventor： Debra Pittman , James R. Apgar , Zong Sean Juo , Macy Jin , Mark Stahl , Gregory J. Carven , Matthew Holsti , Susan Benard , Sunita R. Hett , Reema Jasuja
IPC: C07K16/38 , A61K38/48 , A61K39/395 , A61K39/00
Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
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公开(公告)号：US09751937B2
公开(公告)日：2017-09-05
申请号：US14626321
申请日：2015-02-19
Applicant: PFIZER INC.
Inventor： Michelle M. Mader , James R. Apgar , Kevin D. Parris
IPC: A61K39/00 , A61K39/395 , C07K16/22 , A61K45/06 , C07K16/00
CPC classification number: C07K16/22 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/622 , C07K16/00 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The disclosure provides improved neutralizing anti-GDF-8 antibodies capable of substantially higher levels of expression in host cells compared to previous anti-GDF-8 antibodies. Also provided are methods of using compositions comprising such antibodies to increase muscle mass or strength, and to treat or prevent muscular disorders, neuromuscular disorders, metabolic disorders, adipose tissue disorders or bone disorders.
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公开(公告)号：US20230416405A1
公开(公告)日：2023-12-28
申请号：US18182619
申请日：2023-03-13
Applicant: Pfizer Inc.
Inventor： Debra Pittman , James R. Apgar , Zong Sean Juo , Macy Jin , Mark Stahl , Gregory J. Carven , Matthew Holsti , Susan Benard , Sunita R. Hett , Reema Jasuja
IPC: C07K16/38 , A61K39/00 , A61K38/48 , A61K39/395
CPC classification number: C07K16/38 , A61K39/0011 , A61K38/4846 , A61K39/3955 , C12Y304/21021 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2317/21 , A61K2039/5158 , A61K2039/55522 , C07K2317/565 , C07K2317/622
Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
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公开(公告)号：US20200055930A1
公开(公告)日：2020-02-20
申请号：US16541817
申请日：2019-08-15
Applicant: Pfizer Inc.
Inventor： Kevin Charles Beaumont , Danna M. Breen , Matthew Allister Lambert , Jeffrey Raymond Chabot , Tao He , Ksenya Shchors , James R. Apgar
Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to GDF15, as well as methods and uses for the antibodies.
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公开(公告)号：US11634504B2
公开(公告)日：2023-04-25
申请号：US17102883
申请日：2020-11-24
Applicant: Pfizer Inc.
Inventor： Debra Pittman , James R. Apgar , Zong Sean Juo , Macy Jin , Mark Stahl , Gregory J. Carven , Matthew Holsti , Susan Benard , Sunita R. Hett , Reema Jasuja
IPC: C07K16/38 , A61K39/00 , A61K38/48 , A61K39/395
Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
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Patent Agency Ranking
公开(公告)号：US11566066B2
公开(公告)日：2023-01-31
申请号：US16541817
申请日：2019-08-15
Applicant: Pfizer Inc.
Inventor： Kevin Charles Beaumont , Danna M. Breen , Matthew Allister Lambert , Jeffrey Raymond Chabot , Tao He , Ksenya Shchors , James R. Apgar
Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to GDF15, as well as methods and uses for the antibodies.
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公开(公告)号：US20170073428A1
公开(公告)日：2017-03-16
申请号：US15239556
申请日：2016-08-17
Applicant: Pfizer Inc.
Inventor： Debra Pittman , James R. Apgar , Zong Sean Juo , Macy Jin , Mark Stahl , Gregory J. Carven , Matthew Holsti , Susan Benard , Sunita R. Hett , Reema Jasuja
IPC: C07K16/38 , A61K38/48 , A61K39/395
Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
Abstract translation: 本发明涉及特异性结合TFPI并抑制其活性的抗体及其抗原结合片段。 这样的抗体和片段可用于治疗出血性疾病和缩短凝血时间。
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公开(公告)号：US12227564B2
公开(公告)日：2025-02-18
申请号：US17816484
申请日：2022-08-01
Applicant: Pfizer Inc.
Inventor： Kevin Charles Beaumont , Danna M. Breen , Matthew Allister Lambert , Jeffrey Raymond Chabot , Tao He , Ksenya Shchors , James R. Apgar
Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to GDF15, as well as methods and uses for the antibodies.
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公开(公告)号：US12168698B2
公开(公告)日：2024-12-17
申请号：US18182619
申请日：2023-03-13
Applicant: Pfizer Inc.
Inventor： Debra Pittman , James R. Apgar , Zong Sean Juo , Macy Jin , Mark Stahl , Gregory J. Carven , Matthew Holsti , Susan Benard , Sunita R. Hett , Reema Jasuja
IPC: C07K16/38 , A61K38/48 , A61K39/00 , A61K39/395
Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
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公开(公告)号：US20220380448A1
公开(公告)日：2022-12-01
申请号：US17816484
申请日：2022-08-01
Applicant: Pfizer Inc.
Inventor： Kevin Charles Beaumont , Danna M. Breen , Matthew Allister Lambert , Jeffrey Raymond Chabot , Tao He , Ksenya Shchors , James R. Apgar
Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to GDF15, as well as methods and uses for the antibodies.
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