Invention Grant
- Patent Title: Modified lecithin-cholesterol acyltransferase enzymes
- Patent Title (中): 改性卵磷脂 - 胆固醇酰基转移酶
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Application No.: US14196827Application Date: 2014-03-04
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Publication No.: US09006408B2Publication Date: 2015-04-14
- Inventor: Mingyue Zhou , Wenyan Shen , Bei Shan , Margrit Schwarz , David Park Meininger , Tom Boone
- Applicant: Amgen Inc.
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agency: Marshall, Gerstein & Borun LLP
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12P21/02 ; C12N9/10 ; A61K47/48
Abstract:
The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide.
Public/Granted literature
- US20140287479A1 MODIFIED LECITHIN-CHOLESTEROL ACYLTRANSFERASE ENZYMES Public/Granted day:2014-09-25
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