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公开(公告)号：US20140228547A1
公开(公告)日：2014-08-14
申请号：US14261065
申请日：2014-04-24
Applicant: Amgen, Inc.
Inventor： Simon Mark Jackson , Nigel Pelham Clinton Walker , Derek Evan Piper , Bei Shan , Wenyan Shen , Joyce Chi Yee Chan , Chadwick Terence King , Randal Robert Ketchem , Christopher Mehlin , Teresa Arazas Carabeo , Qiong Cao
IPC: C07K16/40
CPC classification number: C07K16/40 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , A61K31/505 , A61K31/66 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12N15/1137 , A61K2300/00
Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
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公开(公告)号：US20130273024A1
公开(公告)日：2013-10-17
申请号：US13851019
申请日：2013-03-26
Applicant: Amgen Inc.
Inventor： Frank KAYSER , Marc Labelle , Bei Shan , Jian Zhang , Mingyue Zhou
IPC: C12N9/10 , C07D403/12 , C07D417/12
CPC classification number: C12N9/1029 , A61K31/497 , A61K38/45 , C07D403/12 , C07D417/12
Abstract: The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, inflammation, thrombosis and other conditions and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide.
Abstract translation: 本发明提供了通过改变LCAT多肽来治疗动脉粥样硬化，炎症，血栓形成和其它病症并降低或预防受试者胆固醇积聚的化合物，药物组合物和方法。
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公开(公告)号：US09006408B2
公开(公告)日：2015-04-14
申请号：US14196827
申请日：2014-03-04
Applicant: Amgen Inc.
Inventor： Mingyue Zhou , Wenyan Shen , Bei Shan , Margrit Schwarz , David Park Meininger , Tom Boone
CPC classification number: C12N9/1029 , A61K47/68 , C12Y203/01043
Abstract: The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide.
Abstract translation: 本发明提供了通过改变LCAT多肽来治疗动脉粥样硬化，冠心病，血栓形成以及降低或预防受试者胆固醇积聚的化合物，药物组合物和方法。
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4.发明授权Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9) 有权抗原结合蛋白与蛋白转化酶枯草杆菌蛋白酶Kexin 9型（PCSK9）公开(公告)号：US08981064B2
公开(公告)日：2015-03-17
申请号：US14459743
申请日：2014-08-14
Applicant: Amgen Inc.
Inventor： Simon Mark Jackson , Bei Shan , Wenyan Shen , Chadwick Terence King , Randal Robert Ketchem , Christopher Mehlin , Teresa Arazas Carabeo
CPC classification number: C07K16/40 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , A61K31/505 , A61K31/66 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12N15/1137 , A61K2300/00
Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
Abstract translation: 描述了与Proprotein转化酶枯草杆菌蛋白酶Kexin 9型（PCSK9）相互作用的抗原结合蛋白。 描述了通过向PCSK9施用药学有效量的抗原结合蛋白来治疗高胆固醇血症和其它病症的方法。 描述了使用抗原结合蛋白质向PCSK9检测样品中PCSK9的量的方法。
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公开(公告)号：US20140357851A1
公开(公告)日：2014-12-04
申请号：US14459787
申请日：2014-08-14
Applicant: Amgen Inc.
Inventor： Simon Mark Jackson , Nigel Pelham Clinton Walker , Derek Evan Piper , Bei Shan , Wenyan Shen , Joyce Chi Yee Chan , Chadwick Terence King , Randal Robert Ketchem , Christopher Mehlin , Teresa Arazas Carabeo , Qiong Cao
IPC: C07K16/40
CPC classification number: C07K16/40 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , A61K31/505 , A61K31/66 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12N15/1137 , A61K2300/00
Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
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Patent Agency Ranking
6.发明申请MODIFIED LECITHIN-CHOLESTEROL ACYLTRANSFERASE ENZYMES 审中-公开改良的LECITHIN-CHOLESTEROL ACYLTRANSFERASE酶公开(公告)号：US20140287479A1
公开(公告)日：2014-09-25
申请号：US14196827
申请日：2014-03-04
Applicant: Amgen Inc.
Inventor： Mingyue Zhou , Wenyan Shen , Bei Shan , Margrit Schwarz , David Park Meininger , Tom Boone
CPC classification number: C12N9/1029 , A61K47/68 , C12Y203/01043
Abstract: The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide.
Abstract translation: 本发明提供了通过改变LCAT多肽来治疗动脉粥样硬化，冠心病，血栓形成以及降低或预防受试者胆固醇积聚的化合物，药物组合物和方法。
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公开(公告)号：US20130058944A1
公开(公告)日：2013-03-07
申请号：US13655984
申请日：2012-10-19
Applicant: Amgen Inc.
Inventor： Simon Mark Jackson , Nigel Pelham Clinton Walker , Derek Evan Piper , Bei Shan , Wenyan Shen , Joyce Chi Yee Chan , Chadwick Terence King , Randal Robert Ketchem , Christopher Mehlin , Teresa Arazas Carabeo , Qiong Cao
IPC: A61K39/395 , A61P3/06
CPC classification number: C07K16/40 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , A61K31/505 , A61K31/66 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12N15/1137 , A61K2300/00
Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
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公开(公告)号：US09493576B2
公开(公告)日：2016-11-15
申请号：US14459787
申请日：2014-08-14
Applicant: Amgen Inc.
Inventor： Simon Mark Jackson , Nigel Pelham Clinton Walker , Derek Evan Piper , Bei Shan , Wenyan Shen , Chadwick Terence King , Randal Robert Ketchem , Christopher Mehlin , Teresa Arazas Carabeo
IPC: C07K16/40 , A61K39/00 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , A61K31/505 , A61K31/66 , A61K39/395 , A61K45/06 , C12N15/113
CPC classification number: C07K16/40 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , A61K31/505 , A61K31/66 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12N15/1137 , A61K2300/00
Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
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公开(公告)号：US09056915B2
公开(公告)日：2015-06-16
申请号：US14459768
申请日：2014-08-14
Applicant: Amgen Inc.
Inventor： Simon Mark Jackson , Nigel Pelham Clinton Walker , Derek Evan Piper , Bei Shan , Wenyan Shen , Chadwick Terence King , Randal Robert Ketchem , Christopher Mehlin , Teresa Arazas Carabeo
IPC: C07K16/40 , A61K39/00 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , A61K31/505 , A61K31/66 , A61K39/395 , A61K45/06 , C12N15/113
CPC classification number: C07K16/40 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , A61K31/505 , A61K31/66 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12N15/1137 , A61K2300/00
Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
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10.发明申请ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9) 有权抗原蛋白质结合蛋白转移酶突变体KEXIN 9型（PCSK9）公开(公告)号：US20140228545A1
公开(公告)日：2014-08-14
申请号：US14261087
申请日：2014-04-24
Applicant: Amgen, Inc.
Inventor： Simon Mark Jackson , Nigel Pelham Clinton Walker , Derek Evan Piper , Bei Shan , Wenyan Shen , Joyce Chi Yee Chan , Chadwick Terence King , Randal Robert Ketchem , Christopher Mehlin , Teresa Arazas Carabeo , Qiong Cao
IPC: C07K16/40
CPC classification number: C07K16/40 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , A61K31/505 , A61K31/66 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12N15/1137 , A61K2300/00
Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
Abstract translation: 描述了与Proprotein转化酶枯草杆菌蛋白酶Kexin 9型（PCSK9）相互作用的抗原结合蛋白。 描述了通过向PCSK9施用药学有效量的抗原结合蛋白来治疗高胆固醇血症和其它病症的方法。 描述了使用抗原结合蛋白质向PCSK9检测样品中PCSK9的量的方法。
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