公开(公告)号：US09006408B2

公开(公告)日：2015-04-14

申请号：US14196827

申请日：2014-03-04

Applicant: Amgen Inc.

Inventor： Mingyue Zhou ,  Wenyan Shen ,  Bei Shan ,  Margrit Schwarz ,  David Park Meininger ,  Tom Boone

IPC: C07H21/04 ,  C12P21/02 ,  C12N9/10 ,  A61K47/48

CPC classification number: C12N9/1029 ,  A61K47/68 ,  C12Y203/01043

Abstract: The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide.

Abstract translation: 本发明提供了通过改变LCAT多肽来治疗动脉粥样硬化，冠心病，血栓形成以及降低或预防受试者胆固醇积聚的化合物，药物组合物和方法。

公开(公告)号：US20140287479A1

公开(公告)日：2014-09-25

申请号：US14196827

申请日：2014-03-04

Applicant: Amgen Inc.

Inventor： Mingyue Zhou ,  Wenyan Shen ,  Bei Shan ,  Margrit Schwarz ,  David Park Meininger ,  Tom Boone

IPC: C12N9/10 ,  A61K47/48

CPC classification number: C12N9/1029 ,  A61K47/68 ,  C12Y203/01043

Abstract: The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide.

Abstract translation: 本发明提供了通过改变LCAT多肽来治疗动脉粥样硬化，冠心病，血栓形成以及降低或预防受试者胆固醇积聚的化合物，药物组合物和方法。