Invention Grant
- Patent Title: Human cystathionine β-synthase variants and methods of production thereof
- Patent Title (中): 人类胱硫醚和硫酸盐变体及其生产方法
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Application No.: US13826024Application Date: 2013-03-14
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Publication No.: US09011844B2Publication Date: 2015-04-21
- Inventor: Jan P. Kraus
- Applicant: The Regents of the University of Colorado, a Body Corporate
- Applicant Address: US CO Denver
- Assignee: The Regents of the University of Colorado, a Body Corporate
- Current Assignee: The Regents of the University of Colorado, a Body Corporate
- Current Assignee Address: US CO Denver
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- Main IPC: C12N9/88
- IPC: C12N9/88
Abstract:
Human cystathionine β-synthase variants are disclosed, as well as a method to produce recombinant human cystathionine β-synthase and variants thereof. More particularly, the role of both the N-terminal and C-terminal regions of human CBS has been studied, and a variety of truncation mutants and modified CBS homologs are described. In addition, a method to express and purify recombinant human cystathionine β-synthase (CBS) and variants thereof which have only one or two additional amino acid residues at the N-terminus are described.
Public/Granted literature
- US20140023630A1 Human Cystathionine Beta-Synthase Variants and Methods of Production Thereof Public/Granted day:2014-01-23
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