公开(公告)号：US20230135999A1

公开(公告)日：2023-05-04

申请号：US17915201

申请日：2021-04-02

申请人： The Regents of the University of Colorado, A Body Corporate

发明人： Chelsea Magin ,  Cassandra Petrou ,  Rukshika Shalani Hewawasam

IPC分类号： A61L27/52 ,  A61L27/36 ,  A61L27/38 ,  A61L27/14

摘要： The present invention relates in part to hybrid hydrogel scaffolds including a decellularized extracellular matrix (dECM) tissue, and a synthetic polymer. The dECM may include any suitable tissue including for example, lung tissue, heart tissue, heart-lung block tissue, skin tissue, liver tissue, pancreatic tissue, kidney tissue, and the like.

公开(公告)号：US20230119934A1

公开(公告)日：2023-04-20

申请号：US17987710

申请日：2022-11-15

申请人： The Regents of the University of Colorado, a Body Corporate

发明人： CHRISTOPHER N. BOWMAN ,  BRADY T. WORRELL ,  GAYLA BERG LYON ,  MATTHEW K. MCBRIDE ,  CHEN WANG

IPC分类号： C08G75/26 ,  C08G18/77 ,  C08G18/81 ,  C08G18/38 ,  C08G75/045

摘要： The present invention relates to covalent adaptable networks (CANs) having exchangeable crosslinks which are able to undergo repeated covalent bond reshuffling through photo-activation at ambient temperatures. The invention provides covalent adaptable network forming compositions as well as methods of forming, remolding and recycling the CANs of the invention.

公开(公告)号：US20230110354A1

公开(公告)日：2023-04-13

申请号：US18075627

申请日：2022-12-06

申请人： The Regents of the University of Colorado, a Body Corporate

发明人： Jessica Anne Yu Rove ,  Dae Won Park ,  Adam J. Rocker

IPC分类号： A61K31/167 ,  A61K9/51 ,  A61L29/14

摘要： A novel therapeutic agent delivery system, methods of use and methods of formation thereof are presented. The novel delivery system is comprised of novel nanoparticles capable of at least partially encapsulating a therapeutic agent such as an anesthetic, antimicrobial, growth factor or protein. The nanoparticles are embedded with in a crosslinked hydrogel. The hydrogel can be administered directly to a patient or may be coated onto a device such as a catheter. The delivery system allows for a sustained release of the therapeutic agent over an extended period of time.

公开(公告)号：US20230100472A1

公开(公告)日：2023-03-30

申请号：US17789874

申请日：2021-01-08

申请人： The Regents of the University of Colorado, a body corporate ,  Colorado State University Research Foundation

发明人： Steven Sartor ,  Niels Damrauer ,  Garet Miyake ,  Cameron Chrisman ,  Ryan Pearson

IPC分类号： C07D279/30 ,  C07D279/24

摘要： Phenothiazine compounds of Formula (I) are described herein. These compounds are useful as highly reducing organic photoredox catalysts. Suitable substrates for use with the compounds of Formula (I) include acrylates, styrene, acrylamides, acrylonitrile, vinyl chloride, methylacrylonitrile, vinyl acetate, and acrylic acid.

公开(公告)号：US11614402B2

公开(公告)日：2023-03-28

申请号：US16813495

申请日：2020-03-09

申请人： The Regents of the University of Colorado, a body corporate

发明人： Amanda Makowiecki ,  Ryan Cole ,  Nazanin Hoghooghi ,  Greg Rieker

IPC分类号： G01N21/39 ,  G01N21/359 ,  G01N21/3504 ,  G01J3/28 ,  G01N21/27

摘要： A system for recording transmission spectra of a sample with a spectrometer that produces baseline-free molecular response signal. A method for producing baseline-free signals includes applying a logarithmic function to a measured transmission spectrum to form an intermediate spectrum. Applying an inverse Fourier transform to the intermediate spectrum generates a modified free-induction-decay (m-FID) signal, which allows for the separation of molecular absorption features from baseline effects present in the m-FID signal. A weighting function is then applied that suppresses temporal portions of the m-FID signal that correspond to sources of baseline fluctuations as well as periodic effects (e.g. etalons). The method generates a baseline-suppressed m-FID signal that is converted to an absorption spectrum, which exhibits suppressed contributions from baseline fluctuations and periodic effects. When this method is combined with a spectral fitting model it generates measurements of physical properties of the sample without requiring correction for the light source intensity.

公开(公告)号：US20230073248A1

公开(公告)日：2023-03-09

申请号：US17820808

申请日：2022-08-18

申请人： The Regents of the University of Colorado. a body Corporate ,  Angimmune LLC ,  The General Hospital Corporation

发明人： Christene A. Huang ,  David M. Neville, JR. ,  Elizabeth Anne Pomfret ,  Raimon Duran-Struuck ,  Zhirui Wang

IPC分类号： A61K39/395 ,  A61K35/14 ,  A61K38/45 ,  A61K31/436 ,  A61K31/5377 ,  A61K31/573 ,  A61K31/58 ,  A61K31/519 ,  A61K38/13 ,  A61K31/52 ,  A61K31/42 ,  A61P37/06

摘要： Embodiments disclosed herein relate to compositions and methods for inducing transplantation tolerance using immunomodulation agents. In certain embodiments compositions and methods disclosed herein, concern administering a composition including, but not limited to, anti-CD3 immunotoxin and administering a composition including, but not limited to, peripheral blood cells obtained from a donor of an organ, tissue or cells to be transplanted. In some embodiments, compositions and methods disclosed here can be used for modulating B- and/or T-cell-mediated immunity and/or rejection by reducing or eliminating anti-donor antibody production. Other embodiments concern modulating T-cell production in a subject preparing for, undergoing organ, tissue or cellular transplantation; or having or expected of developing GvHD for reducing the risk of, preventing or treating rejection or GvHD. In certain embodiments, combination compositions of anti-CD3 immunotoxin and peripheral blood cells from a donor are contemplated.

公开(公告)号：US11597798B2

公开(公告)日：2023-03-07

申请号：US17112865

申请日：2020-12-04

申请人： The Regents of the University of Colorado, A Body Corporate

发明人： Josef Michl ,  Thomas Frank Magnera

IPC分类号： C08G61/12 ,  C08G85/00

摘要： Methods of forming a porphene polymeric material are provided. The resulting material can be a porphene or a metalloporphene polymeric material. The structure of the polymer can be selected based on a material provided in the monomer material. Methods of using the polymeric material are also provided.

公开(公告)号：US20230064628A1

公开(公告)日：2023-03-02

申请号：US17900856

申请日：2022-08-31

申请人： The Regents of the University of Colorado, a body Corporate

发明人： Kai Yu ,  Xu He ,  Martin Dunn ,  Arif Abdullah

IPC分类号： B29C64/209 ,  B29C64/165 ,  B29C64/227 ,  B29C64/264 ,  B29C64/336

摘要： A printer head for three-dimensional printing of a continuous fiber-reinforced thermoset composite may include a deposition syringe, a fiber housing, and a feeding tube. The deposition syringe may define a resin reservoir, an air chamber, and a first inlet port configured to deliver a first flow of air to the air chamber. The deposition syringe may include a syringe body and a piston. The syringe body may include an inlet section, a needle section, and a converging section disposed between the inlet section and the needle section. The fiber housing may define a fiber chamber and a second inlet port configured to deliver a second flow of air to the fiber chamber. The feeding tube may extend from the fiber chamber to the needle section and may be configured to receive the second flow of air therein and to guide a fiber from the fiber chamber to the needle section.

公开(公告)号：US11589776B2

公开(公告)日：2023-02-28

申请号：US16676346

申请日：2019-11-06

申请人： The Regents of the University of Colorado, a body corporate

发明人： Min-Hyung Choi ,  Shane Transue ,  Ann Halbower

IPC分类号： A61B5/087 ,  A61B5/00 ,  A61B5/091 ,  G16H30/40 ,  G06T5/10 ,  G06T7/00 ,  G06T17/10

摘要： Various embodiments of the disclosed technology present a structural foundation for volumetric flow reconstructions for expiratory modeling enabled through multi-modal imaging for pulmonology. In some embodiments, this integrated multi-modal system includes infrared (IR) imaging, thermal imaging of carbon dioxide (CO2), depth imaging (D), and visible spectrum imaging. These multiple image modalities can be integrated into flow models of exhale behaviors enable the creation of three-dimensional volume reconstructions based on visualized CO2 distributions over time, formulating a four-dimensional exhale model which can be used to estimate various pulmonological traits (e.g., breathing rate, flow rate, exhale velocity, nose/mouth distribution, tidal volume estimation, and CO2 density distributions). Various embodiments also enable the accurate acquisition of numerous pulmonary metrics that are then stored within distributed systems for respiratory data analytics and feature extraction through deep learning embodiments.

公开(公告)号：US11547603B2

公开(公告)日：2023-01-10

申请号：US16901906

申请日：2020-06-15

申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

发明人： Malik Y. Kahook

IPC分类号： A61F9/007 ,  A61B17/3211 ,  A61B17/32

摘要： A microsurgical device and methods of its use can be used for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. A dual-blade device can be used for cutting the trabecular meshwork (“TM”) in the eye. The device tip provides entry into the Schlemm's canal via its size (i.e., for example, 0.2-0.3 mm width) and configuration where a ramp elevates the TM away from the outer wall of the Schlemm's canal and guides the TM to first and second lateral elements for creating first and second incisions through the TM. The dimensions and configuration of the blade is such that an entire strip of TM is removed without leaving TM leaflets behind and without causing collateral damage to adjacent tissues.