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公开(公告)号：US12132387B2
公开(公告)日：2024-10-29
申请号：US17629066
申请日：2020-07-22
发明人： Robert Erickson , Aaron Rogers , Roger Bell
IPC分类号： H02M7/48 , H02M1/00 , H02M7/5387
CPC分类号： H02M1/0043 , H02M1/0058 , H02M1/0085 , H02M1/009 , H02M7/4807 , H02M7/53871
摘要： Inverters that interface dc and ac power sources and loads are provided. An example application is solar power systems, in which a dc source of power is an array of solar panels; the inverter converts the dc power supplied by these panels to ac power that is fed into the utility grid. Another example is battery energy storage; the inverter changes the dc power of the batteries into ac power that is fed into the grid, and also can convert (rectify) ac power from the grid for charging the batteries. In one embodiment, for example, an inverter comprises slow switches that generate a three-level ac voltage, followed by a plurality of fast-switching half-bridges that introduce high-frequency pulse-width modulation into a plurality of ac output voltages.
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公开(公告)号：US20240345012A1
公开(公告)日：2024-10-17
申请号：US18633902
申请日：2024-04-12
发明人： Mujtaba Al Hubayl , Hayden Holtrop , Pandora Down , Brandon Muckenthaler , Jack McHale , Miguel Bermudez , Elliot Strand , Gregory Whiting , Luke Richard Borgerding
IPC分类号： G01N27/04 , G01N33/487
CPC分类号： G01N27/04 , G01N33/487
摘要： A testing apparatus includes a first section defining a recess to receive and align a transducer and an alignment protrusion. The testing apparatus further includes a second section hinge-ably coupled to the first section and defining a sample port and an alignment opening. The testing apparatus includes a gasket insert disposed within the sample port and defining at least one well configured to receive a fluid therein and align with a first portion of the transducer. A connector is coupled to the second section, the connector having a plurality of flexible or spring-loaded contact pins that align with a second portion of the transducer. The testing apparatus is movable between (i) an open configuration wherein the first section is disposed at an angle with respect to the second section and (ii) a closed configuration wherein the alignment protrusion is disposed within the alignment opening.
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公开(公告)号：US20240342662A1
公开(公告)日：2024-10-17
申请号：US18292758
申请日：2021-07-29
CPC分类号： B01D69/1411 , B01D53/228 , B01D67/00793 , B01D71/0281 , B01D71/40 , B01D2257/504 , B01D2323/30
摘要： The invention relates to a composition comprising: at least one porous solid additive having a charged surface; an IL; a polymerizable IL; and a cross-linker; wherein the cross-linker wherein the cross-linker has a high affinity to CO2 over other light gas and comprises at least two polymerizable groups configured to react, in a radical polymerization reaction, with the polymerizable ionic liquid, said polymerizable groups preferably containing double bond.
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公开(公告)号：US20240342463A1
公开(公告)日：2024-10-17
申请号：US18602488
申请日：2024-03-12
IPC分类号： A61M60/863 , A61B17/02 , A61B17/11 , A61B17/3207 , A61B17/34 , A61B90/00
CPC分类号： A61M60/863 , A61B17/320708 , A61B17/3468 , A61B90/02 , A61B2017/0243 , A61B2017/1103
摘要： A synchronous drive system for simultaneously driving more than two or more rotational tissue screws and a method for simultaneously affixing a medical device to tissue employing the synchronous drive system. The synchronous drive system is particularly configured to affix an apical cuff to cardiac muscle tissue by simultaneously driving a plurality of rotational tissue screws through the apical cuff and into cardiac muscle tissue thereby affixing the apical cuff to the cardiac muscle tissue.
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公开(公告)号：US12104856B2
公开(公告)日：2024-10-01
申请号：US15787455
申请日：2017-10-18
发明人： Ryan John Lewis , Ronggui Yang , Yung-Cheng Lee
IPC分类号： F28D15/04 , F28D15/02 , H01L23/427 , H01L23/433 , B23P15/26
CPC分类号： F28D15/046 , F28D15/02 , F28D15/0233 , F28D15/04 , H01L23/427 , H01L23/433 , B23P15/26
摘要： Some embodiments of the invention include a thermal ground plane with a variable thickness vapor core. For example, a thermal ground plan may include a first casing and a second casing where the second casing and the first casing configured to enclose a working fluid. The thermal ground plane may also include an evaporator region disposed at least partially on at least one of the first casing and the second casing; a condenser region disposed at least partially on at least one of the first casing and the second casing; and a wicking layer disposed between the first casing and the second casing a vapor core defined at least partially by a gap between the first casing and the second casing. The thickness of the gap can vary across the first casing and the second casing.
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公开(公告)号：US12097291B2
公开(公告)日：2024-09-24
申请号：US17316585
申请日：2021-05-10
IPC分类号： A61K39/395 , A61K9/19 , A61K39/00 , A61K39/39 , A61K47/26
CPC分类号： A61K9/19 , A61K39/00 , A61K39/39 , A61K47/26 , A61K2039/55505 , A61K2039/55572 , Y02A50/30
摘要： Compositions relating to thermostable vaccines and methods of preparing the same. Specifically, methods of preparing thermostable vaccines based on a recombinant ricin neurotoxin protein and uses of co-adjuvants to develop a composition capable of eliciting an immune response in a subject.
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公开(公告)号：US20240315062A1
公开(公告)日：2024-09-19
申请号：US18604365
申请日：2024-03-13
申请人： Alliance for Sustainable Energy, LLC , The Regents of the University of Colorado, a body corporate
摘要： The present disclosure relates to a device that includes a first metal oxide layer having a first thickness, a second metal oxide layer having a second thickness, and a base layer having a third thickness, where the first metal oxide layer is positioned between the base layer and the second metal oxide layer, at least one of the base layer and/or the first metal oxide layer includes a carbon-containing material, and at least one of a carbon concentration gradient and/or an oxygen concentration gradient is present across at least one of a portion of the first thickness and/or a portion of the third thickness. In some embodiments of the present disclosure, the first metal oxide layer may be permeable to an oxygen-containing compound. In some embodiments of the present disclosure, the oxygen-containing compound may include at least one of O3, N2O, and/or H2O2.
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公开(公告)号：US20240264460A1
公开(公告)日：2024-08-08
申请号：US18289878
申请日：2022-05-09
发明人： Kelvin Wagner , Nathan Dostart , Michael P. Brand , Milos Popovic , Bohan Zhang
CPC分类号： G02B27/4272 , G01J3/0259 , G01J3/1804 , G01J3/2803 , G02B5/188
摘要： A serpentine integrated grating spectrometer includes a serpentine delay line and a plurality of grating couplers. The serpentine delay line includes a plurality of parallel waveguide segments that are coplanar in a delay-line plane. The serpentine delay line serially connects each of the plurality of grating couplers. Each of the plurality of grating couplers (i) is located at a respective one of the plurality of parallel waveguide segments, and (ii) direct light propagating in the serpentine delay line out of the delay-line plane. The plurality of waveguide segments is M in number and impart a total group delay time ry on light propagating therethrough. Each of the plurality of grating couplers impart a grating coupler delay tx on light propagating therethrough that exceeds (ty/M), the time delay for a single segment of the M parallel segments.
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公开(公告)号：US20240217180A1
公开(公告)日：2024-07-04
申请号：US18288713
申请日：2022-04-28
IPC分类号： B29C64/393 , A61C7/08 , B29C64/124 , B29C64/241 , B29L31/00 , B33Y10/00 , B33Y30/00 , B33Y50/02 , B33Y80/00
CPC分类号： B29C64/393 , A61C7/08 , B29C64/124 , B29C64/241 , B33Y10/00 , B33Y30/00 , B33Y50/02 , B33Y80/00 , B29L2031/753
摘要： Systems and methods for improved volumetric additive manufacturing (VAM) are described herein. In some aspects of the present disclosure, approaches to VAM image-computation are provided that algebraically optimizes directly on the structure to be printed, instead of on the set of external projection images. These approaches provide multiple advantages including improved reconstruction fidelity, simplicity, flexibility, and robust convergence to a desirable reconstruction, regardless of initial image-set guess.
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公开(公告)号：US12018081B1
公开(公告)日：2024-06-25
申请号：US17006635
申请日：2020-08-28
CPC分类号： C07K16/2863 , A61K33/16 , C12N9/78 , A61K2039/505 , C12Y305/04001
摘要： A prodrug enzyme covalently photoconjugated to a live cell receptor survives endosomal proteolysis and retains its catalytic activity on the living cell membrane over multiple days. Antibody-directed enzyme prodrug therapy is a promising approach for selective treatment of solid tumors, but methods are needed to preserve enzyme activity on living cell membranes over multiple prodrug dosings. A fusion protein was designed with both an anti-epidermal growth factor receptor (EGFR) affibody and the prodrug enzyme cytosine deaminase, which can convert prodrug 5-fluorocytosine to the anticancer drug 5-fluorouracil. A benzophenone group was added at a site-specific mutation within the affibody portion, and the fusion protein was selectively and irreversibly photoconjugated to EGFR receptors expressed on membranes of live MDA-MB-468 breast cancer cells. Affinity-mediated covalent conjugation of the affibody-enzymes to cell receptors allows for prolonged expression on membranes and retained enzymatic activity without genetic engineering.
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