发明授权
US09017668B2 High affinity human antibodies to human cytomegalovirus (CMV) gB protein
有权
人类巨细胞病毒（CMV）gB蛋白的高亲和力人抗体
- 专利标题： High affinity human antibodies to human cytomegalovirus (CMV) gB protein
- 专利标题（中）： 人类巨细胞病毒（CMV）gB蛋白的高亲和力人抗体
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申请号： US13162497申请日： 2011-06-16
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公开(公告)号： US09017668B2公开(公告)日： 2015-04-28
- 发明人: Lawrence M. Kauvar , Stote Ellsworth , William Usinger , Krista Maureen McCutcheon , Ying-Ping Jiang , Fen Zhang , Bo Chen , Gizette Sperinde , Minha Park , Orit Foord
- 申请人： Lawrence M. Kauvar , Stote Ellsworth , William Usinger , Krista Maureen McCutcheon , Ying-Ping Jiang , Fen Zhang , Bo Chen , Gizette Sperinde , Minha Park , Orit Foord
- 申请人地址： US CA Menlo Park
- 专利权人： Trellis Bioscience, LLC
- 当前专利权人： Trellis Bioscience, LLC
- 当前专利权人地址： US CA Menlo Park
- 代理机构： Morrison & Foerster LLP
- 主分类号： A61K39/12
- IPC分类号： A61K39/12 ; A61K39/215 ; C07K16/08 ; C07K16/46
摘要：
Antibodies to human Cytomegalovirus (CMV) gB protein have been isolated from human B cells. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.
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