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1.发明授权High affinity human antibodies to human cytomegalovirus (CMV) gB protein 有权人类巨细胞病毒（CMV）gB蛋白的高亲和力人抗体公开(公告)号：US09017668B2
公开(公告)日：2015-04-28
申请号：US13162497
申请日：2011-06-16
申请人： Lawrence M. Kauvar , Stote Ellsworth , William Usinger , Krista Maureen McCutcheon , Ying-Ping Jiang , Fen Zhang , Bo Chen , Gizette Sperinde , Minha Park , Orit Foord
发明人： Lawrence M. Kauvar , Stote Ellsworth , William Usinger , Krista Maureen McCutcheon , Ying-Ping Jiang , Fen Zhang , Bo Chen , Gizette Sperinde , Minha Park , Orit Foord
IPC分类号： A61K39/12 , A61K39/215 , C07K16/08 , C07K16/46
CPC分类号： C07K16/088 , A61K39/245 , A61K2039/505 , C07K16/08 , C07K16/468 , C07K2317/14 , C07K2317/21 , C07K2317/30 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Antibodies to human Cytomegalovirus (CMV) gB protein have been isolated from human B cells. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.
摘要翻译： 已从人B细胞中分离出人巨细胞病毒（CMV）gB蛋白的抗体。 这些抗体的亲和力高于先前报道的最佳抗体。 由于高亲和力对于预防跨越胎盘的病毒转移至关重要，本发明的抗体可用作预防或改善对怀孕期间CMV感染胎儿的影响的治疗和预防剂。
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公开(公告)号：US08362215B2
公开(公告)日：2013-01-29
申请号：US12770674
申请日：2010-04-29
申请人： Bruce Keyt , Lawrence M. Kauvar , Ellen J. Collarini , Orit Foord , Gizette Sperinde , Marjan Fatholahi , Hung Nguyen
发明人： Bruce Keyt , Lawrence M. Kauvar , Ellen J. Collarini , Orit Foord , Gizette Sperinde , Marjan Fatholahi , Hung Nguyen
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： C07K16/2863 , C07K16/22 , C07K16/30 , C07K16/32 , C07K16/40 , C07K2317/32 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： Antibodies which specifically bind heregulin-coupled HER3, at a site distinct from the heregulin binding site, are described. These antibodies are particularly useful in treating cancer.
摘要翻译： 描述了在不同于调节蛋白结合位点的位点上特异性结合随机结合的HER3的抗体。 这些抗体特别可用于治疗癌症。
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公开(公告)号：US07736648B2
公开(公告)日：2010-06-15
申请号：US12258260
申请日：2008-10-24
申请人： Lawrence M. Kauvar , Ellen J. Collarini , Bruce Keyt , Orit Foord
发明人： Lawrence M. Kauvar , Ellen J. Collarini , Bruce Keyt , Orit Foord
CPC分类号： C07K16/1027 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/76 , C07K2317/92 , C12N2740/11011
摘要： Individual monoclonal antibodies and fragments that bind a conserved epitope of the G protein of RSV and which are minimally immunogenic when administered to a human subject, are useful in treating RSV infections.
摘要翻译： 单独的单克隆抗体和结合RSV的G蛋白的保守表位并且当施用于人受试者时具有最低免疫原性的片段可用于治疗RSV感染。
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公开(公告)号：US08273354B2
公开(公告)日：2012-09-25
申请号：US12778933
申请日：2010-05-12
申请人： Lawrence M. Kauvar , Ellen J. Collarini , Bruce Keyt , Orit Foord
发明人： Lawrence M. Kauvar , Ellen J. Collarini , Bruce Keyt , Orit Foord
CPC分类号： C07K16/1027 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/76 , C07K2317/92 , C12N2740/11011
摘要： Individual monoclonal antibodies and fragments that bind a conserved epitope of the G protein of RSV and which are minimally immunogenic when administered to a human subject, are useful in treating RSV infections.
摘要翻译： 单独的单克隆抗体和结合RSV的G蛋白的保守表位并且当施用于人受试者时具有最低免疫原性的片段可用于治疗RSV感染。
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公开(公告)号：US20090130120A1
公开(公告)日：2009-05-21
申请号：US12258260
申请日：2008-10-24
申请人： Lawrence M. KAUVAR , Ellen J. Collarini , Bruce Keyt , Orit Foord
发明人： Lawrence M. KAUVAR , Ellen J. Collarini , Bruce Keyt , Orit Foord
IPC分类号： A61K39/395 , C07K16/18 , C12N15/11 , C12N5/06 , C12N5/04 , C12P21/04 , A01K67/027 , A01H5/00
CPC分类号： C07K16/1027 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/76 , C07K2317/92 , C12N2740/11011
摘要： Individual monoclonal antibodies and fragments that bind a conserved epitope of the G protein of RSV and which are minimally immunogenic when administered to a human subject, are useful in treating RSV infections.
摘要翻译： 单独的单克隆抗体和结合RSV的G蛋白的保守表位并且当施用于人受试者时具有最低免疫原性的片段可用于治疗RSV感染。
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公开(公告)号：US20130034564A1
公开(公告)日：2013-02-07
申请号：US13626852
申请日：2012-09-25
申请人： Lawrence M. KAUVAR , Ellen J. Collarini , Bruce Keyt , Orit Foord
发明人： Lawrence M. KAUVAR , Ellen J. Collarini , Bruce Keyt , Orit Foord
IPC分类号： A61K39/42 , C12N15/13 , A61K39/395 , C12N5/10 , A61P11/00 , C12P21/08 , A01K67/00 , A01H5/00 , C07K16/00 , A61P31/14
CPC分类号： C07K16/1027 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/76 , C07K2317/92 , C12N2740/11011
摘要： Individual monoclonal antibodies and fragments that bind a conserved epitope of the G protein of RSV and which are minimally immunogenic when administered to a human subject, are useful in treating RSV infections.
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公开(公告)号：US20100285022A1
公开(公告)日：2010-11-11
申请号：US12778933
申请日：2010-05-12
申请人： Lawrence M. KAUVAR , Ellen J. Collarini , Bruce Keyt , Orit Foord
发明人： Lawrence M. KAUVAR , Ellen J. Collarini , Bruce Keyt , Orit Foord
CPC分类号： C07K16/1027 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/76 , C07K2317/92 , C12N2740/11011
摘要： Individual monoclonal antibodies and fragments that bind a conserved epitope of the G protein of RSV and which are minimally immunogenic when administered to a human subject, are useful in treating RSV infections.
摘要翻译： 单独的单克隆抗体和结合RSV的G蛋白的保守表位并且当施用于人受试者时具有最低免疫原性的片段可用于治疗RSV感染。
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公开(公告)号：US09320812B2
公开(公告)日：2016-04-26
申请号：US13992599
申请日：2011-12-07
申请人： Johannes Hampl , Scott J. Dylla , Orit Foord , Robert A. Stull
发明人： Johannes Hampl , Scott J. Dylla , Orit Foord , Robert A. Stull
CPC分类号： C07K16/18 , A61K38/47 , A61K47/64 , A61K47/6455 , A61K47/6811 , A61K47/6815 , A61K47/6855 , A61K47/6867 , A61K47/6869 , A61K47/6891 , C07K16/28 , C07K16/2809 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/3061 , C07K16/3069 , C07K16/40 , C07K2317/14 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12Y302/02022 , G01N33/574
摘要： Novel modulators, including antibodies and derivatives thereof, and methods of such modulators to treat hyperproliferative disorders are provided.
摘要翻译： 提供了新型调节剂，包括抗体及其衍生物，以及这些调节剂治疗过度增殖性疾病的方法。
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9.发明授权公开(公告)号：US09062113B2
公开(公告)日：2015-06-23
申请号：US12268363
申请日：2008-11-10
申请人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su
发明人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6849 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/77 , C07K2317/92 , Y10S435/81
摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.
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公开(公告)号：US20140105888A1
公开(公告)日：2014-04-17
申请号：US14000289
申请日：2012-02-17
申请人： Orit Foord , Scott J. Dylla , Robert A. Stull , Alex Bankovich , Alexandra Leida Liana Lazetic , Jeffrey Bernstein
发明人： Orit Foord , Scott J. Dylla , Robert A. Stull , Alex Bankovich , Alexandra Leida Liana Lazetic , Jeffrey Bernstein
CPC分类号： C07K16/32 , A61K47/6803 , A61K47/6851 , C07K16/30 , C07K16/40 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C12N2740/15043
摘要： Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat hyperproliferative disorders are provided.
摘要翻译： 提供了新型调节剂，包括抗体及其衍生物，以及使用这些调节剂治疗过度增殖性疾病的方法。
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