发明授权
- 专利标题: Synthesis of 18F-labeled tracers in hydrous organic solvents
- 专利标题(中): 在含水有机溶剂中合成18F标记的示踪剂
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申请号: US13634708申请日: 2011-04-08
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公开(公告)号: US09023316B2公开(公告)日: 2015-05-05
- 发明人: Umesh Gangadharmath , Joseph Walsh , Hartmuth Kolb
- 申请人: Umesh Gangadharmath , Joseph Walsh , Hartmuth Kolb
- 申请人地址: US PA Malvern
- 专利权人: Siemens Medical Solutions USA, Inc.
- 当前专利权人: Siemens Medical Solutions USA, Inc.
- 当前专利权人地址: US PA Malvern
- 代理商 Peter Kendall
- 国际申请: PCT/US2011/031681 WO 20110408
- 国际公布: WO2011/127345 WO 20111013
- 主分类号: C07B59/00
- IPC分类号: C07B59/00 ; B01D15/36 ; A61K51/04
摘要:
A method for synthesizing an 18F-labeled probe. The method includes a step of eluting an amount of 18F with a first solvent which includes a predetermined amount of water and at least one organic solvent. In this step, the 18F elutes as an 18F solution. The method also includes a step of using the 18F solution to perform 18F-labeling in the presence of at least one labeling reagent and at least one phase transfer catalyst so as to generate the 18F-labeled probe. In the method, there is no step of drying the 18F starting from a time when the eluting step is performed and ending at a time when the 18F-labeling step is performed.
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