发明授权
US09023316B2 Synthesis of 18F-labeled tracers in hydrous organic solvents 有权
在含水有机溶剂中合成18F标记的示踪剂

Synthesis of 18F-labeled tracers in hydrous organic solvents
摘要:
A method for synthesizing an 18F-labeled probe. The method includes a step of eluting an amount of 18F with a first solvent which includes a predetermined amount of water and at least one organic solvent. In this step, the 18F elutes as an 18F solution. The method also includes a step of using the 18F solution to perform 18F-labeling in the presence of at least one labeling reagent and at least one phase transfer catalyst so as to generate the 18F-labeled probe. In the method, there is no step of drying the 18F starting from a time when the eluting step is performed and ending at a time when the 18F-labeling step is performed.
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