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公开(公告)号：US09023316B2
公开(公告)日：2015-05-05
申请号：US13634708
申请日：2011-04-08
申请人： Umesh Gangadharmath , Joseph Walsh , Hartmuth Kolb
发明人： Umesh Gangadharmath , Joseph Walsh , Hartmuth Kolb
CPC分类号： B01D15/363 , A61K51/04 , A61K51/0448 , A61K51/0453 , A61K51/0455 , A61K51/0459 , A61K51/047 , A61K51/0491
摘要： A method for synthesizing an 18F-labeled probe. The method includes a step of eluting an amount of 18F with a first solvent which includes a predetermined amount of water and at least one organic solvent. In this step, the 18F elutes as an 18F solution. The method also includes a step of using the 18F solution to perform 18F-labeling in the presence of at least one labeling reagent and at least one phase transfer catalyst so as to generate the 18F-labeled probe. In the method, there is no step of drying the 18F starting from a time when the eluting step is performed and ending at a time when the 18F-labeling step is performed.
摘要翻译： 合成18F标记的探针的方法。 该方法包括用包含预定量的水和至少一种有机溶剂的第一溶剂洗脱一定量的18F的步骤。 在这一步中，18F洗脱为18F溶液。 该方法还包括使用18F溶液在存在至少一种标记试剂和至少一种相转移催化剂的情况下进行18F标记以产生18F标记的探针的步骤。 在该方法中，从执行洗脱步骤的时间开始并且在进行18F标记步骤的时刻结束时，没有干燥18F的步骤。
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公开(公告)号：US07928210B2
公开(公告)日：2011-04-19
申请号：US12074538
申请日：2008-03-03
申请人： Hartmuth C. Kolb , Joseph C. Walsh , Robert M Yeh , Kai Chen , Umesh Gangadharmath , Brian Duclos , Vani P. Mocharla , Farhad Karimi , Henry C. Padgett , Qianwa Liang , Tieming Zhao
发明人： Hartmuth C. Kolb , Joseph C. Walsh , Robert M Yeh , Kai Chen , Umesh Gangadharmath , Brian Duclos , Vani P. Mocharla , Farhad Karimi , Henry C. Padgett , Qianwa Liang , Tieming Zhao
CPC分类号： C07H19/073 , A61K51/0491 , C07H19/06 , C07H19/067
摘要： Disclosed herein are novel radiolabeled nucleosides and methods for detecting cellular proliferation in a mammal, the method comprising administrating an effective amount of a radiolabeled nucleoside; the method comprising: a) administering to the mammal a diagnostically effective amount of the nucleoside to the mammal; b) allowing the nucleoside to distribute into the effective tissue; and c) imaging the tissue, wherein an increase in binding of the compound to tissue compared to a normal control level of binding indicates that the mammal is suffering from a disease involving cellular proliferation.
摘要翻译： 本文公开了新型放射性标记核苷和用于检测哺乳动物细胞增殖的方法，该方法包括施用有效量的放射性标记的核苷; 所述方法包括：a）向哺乳动物施用诊断有效量的核苷; b）允许核苷分布到有效组织中; 和c）对所述组织进行成像，其中与正常对照结合水平相比，所述化合物与组织的结合增加指示所述哺乳动物患有涉及细胞增殖的疾病。
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公开(公告)号：US20090016958A1
公开(公告)日：2009-01-15
申请号：US12074538
申请日：2008-03-03
申请人： Hartmuth C. Kolb , Joseph C. Walsh , Robert M. Yeh , Kai Chen , Umesh Gangadharmath , Brian Duclos , Vani P. Mocharla , Farhad Karimi , Henry C. Padgett , Qianwa Liang , Tieming Zhao
发明人： Hartmuth C. Kolb , Joseph C. Walsh , Robert M. Yeh , Kai Chen , Umesh Gangadharmath , Brian Duclos , Vani P. Mocharla , Farhad Karimi , Henry C. Padgett , Qianwa Liang , Tieming Zhao
CPC分类号： C07H19/073 , A61K51/0491 , C07H19/06 , C07H19/067
摘要： Disclosed herein are novel radiolabeled nucleosides and methods for detecting cellular proliferation in a mammal, the method comprising administrating an effective amount of a radiolabeled nucleoside; the method comprising: a) administering to the mammal a diagnostically effective amount of the nucleoside to the mammal; b) allowing the nucleoside to distribute into the effective tissue; and c) imaging the tissue, wherein an increase in binding of the compound to tissue compared to a normal control level of binding indicates that the mammal is suffering from a disease involving cellular proliferation.
摘要翻译： 本文公开了新型放射性标记核苷和用于检测哺乳动物细胞增殖的方法，该方法包括施用有效量的放射性标记的核苷; 所述方法包括：a）向哺乳动物施用诊断有效量的核苷; b）允许核苷分布到有效组织中; 和c）对所述组织进行成像，其中与正常对照结合水平相比，所述化合物与组织的结合增加指示所述哺乳动物患有涉及细胞增殖的疾病。
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4.发明申请公开(公告)号：US20080213175A1
公开(公告)日：2008-09-04
申请号：US11901704
申请日：2007-09-17
申请人： Hartmuth C. Kolb , Kai Chen , Joseph C. Walsh , Umesh Gangadharmath , Dhanalakshmi Kasi , Bing Wang , Brian Duclos , Qianwa Liang , Henry Clifton Padgett , Farhad Karimi
发明人： Hartmuth C. Kolb , Kai Chen , Joseph C. Walsh , Umesh Gangadharmath , Dhanalakshmi Kasi , Bing Wang , Brian Duclos , Qianwa Liang , Henry Clifton Padgett , Farhad Karimi
CPC分类号： C07K7/56
摘要： The present application is directed to radiolabeled cyclic peptidomimetics, pharmaceutical compositions comprising radiolabeled cyclic peptidomimetics, and methods of using the radiolabeled cyclic peptidomimetics. Such peptidomimetics can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).
摘要翻译： 本申请涉及放射性标记的环肽模拟物，包含放射性标记的环肽模拟物的药物组合物，以及使用放射性标记的环肽模拟物的方法。 这种肽模拟物可用于成像研究，例如正电子发射断层扫描（PET）或单光子发射计算机断层扫描（SPECT）。
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公开(公告)号：US20130005956A1
公开(公告)日：2013-01-03
申请号：US13634708
申请日：2011-04-08
申请人： Umesh Gangadharmath , Joseph Walsh , Hartmuth Kolb
发明人： Umesh Gangadharmath , Joseph Walsh , Hartmuth Kolb
IPC分类号： C07B59/00 , C09K3/00 , C07H5/02 , C07D417/12 , C07D403/06 , C07H19/06
CPC分类号： B01D15/363 , A61K51/04 , A61K51/0448 , A61K51/0453 , A61K51/0455 , A61K51/0459 , A61K51/047 , A61K51/0491
摘要： A method for synthesizing an 18F-labeled probe. The method includes a step of eluting an amount of 18F with a first solvent which includes a predetermined amount of water and at least one organic solvent. In this step, the 18F elutes as an 18F solution. The method also includes a step of using the 18F solution to perform 18F-labeling in the presence of at least one labeling reagent and at least one phase transfer catalyst so as to generate the 18F-labeled probe. In the method, there is no step of drying the 18F starting from a time when the eluting step is performed and ending at a time when the 18F-labeling step is performed.
摘要翻译： 合成18F标记的探针的方法。 该方法包括用包含预定量的水和至少一种有机溶剂的第一溶剂洗脱一定量的18F的步骤。 在这一步中，18F洗脱为18F溶液。 该方法还包括使用18F溶液在存在至少一种标记试剂和至少一种相转移催化剂的情况下进行18F标记以产生18F标记的探针的步骤。 在该方法中，从执行洗脱步骤的时间开始并且在进行18F标记步骤的时刻结束时，没有干燥18F的步骤。
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公开(公告)号：US20130005972A1
公开(公告)日：2013-01-03
申请号：US13634308
申请日：2011-03-29
IPC分类号： C07C231/10 , C07C269/06 , C07D239/95 , C07D233/91 , C07D403/06
CPC分类号： C07B59/00
摘要： A method for generating a radiolabeled tracer. The method includes providing a phosphine molecule having at least one carbocyclic, aromatic, or pyrrolidinyl ring with an OH substitute. The OH of this phosphines molecule is then condensed with an acid to produce a phosphine ester. Staudinger ligation is then performed to generate the radiolabeled tracer by treating the phosphine ester with a radiolabeled azide having a PET radioisotope moiety.
摘要翻译： 一种产生放射性标记示踪剂的方法。 该方法包括提供具有至少一个具有OH取代基的碳环，芳族或吡咯烷基环的膦分子。 然后将该膦分子的OH与酸缩合以产生膦酯。 然后通过用具有PET放射性同位素部分的放射性标记的叠氮化物处理膦酯来进行施陶丁格连接以产生放射性标记的示踪剂。
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