Invention Grant
- Patent Title: Substituted isoquinolinones and quinazolinones
- Patent Title (中): 取代的异喹啉酮和喹唑啉酮
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Application No.: US13778910Application Date: 2013-02-27
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Publication No.: US09051279B2Publication Date: 2015-06-09
- Inventor: Joerg Berghausen , Nicole Buschmann , Pascal Furet , Francois Gessier , Joanna Hergovich Lisztwan , Philipp Holzer , Edgar Jacoby , Joerg Kallen , Keiichi Masuya , Carole Pissot Soldermann , Haixia Ren , Stefan Stutz
- Applicant: Novartis AG
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Scott W. Reid
- Priority: WOPCT/CN2010/078927 20101119
- Main IPC: C07D239/82
- IPC: C07D239/82 ; A01N43/54 ; A61K31/517 ; C07D217/24 ; C07D401/04 ; C07D401/10 ; C07D401/12 ; C07D401/14 ; C07D405/04 ; C07D405/12 ; C07D405/14 ; C07D409/12 ; C07D413/10 ; C07D413/12 ; C07D413/14 ; C07D417/12
Abstract:
The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I) wherein Z is CH2 or N—R4 and X, R1, R2, R4, R6, R7 and n are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.
Public/Granted literature
- US20130281473A1 SUBSTITUTED ISOQUINOLINONES AND QUINAZOLINONES Public/Granted day:2013-10-24
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