- 专利标题： Mutations in the BCR-ABL tyrosine kinase associated with resistance to STI-571
-
申请号： US12080596申请日： 2008-04-04
-
公开(公告)号： US09056924B2公开(公告)日： 2015-06-16
- 发明人: Charles L. Sawyers , Mercedes E. Gorre , Neil Pravin Shah , John Nicoll
- 申请人： Charles L. Sawyers , Mercedes E. Gorre , Neil Pravin Shah , John Nicoll
- 申请人地址： US CA Oakland
- 专利权人： The Regents of the University of California
- 当前专利权人： The Regents of the University of California
- 当前专利权人地址： US CA Oakland
- 代理机构： Ropes & Gray LLP
- 代理商 James F. Haley, Jr.; Qianru Li
- 主分类号： C12Q1/00
- IPC分类号： C12Q1/00 ; C07K14/82 ; C12Q1/48 ; C12Q1/68
摘要：
The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
公开/授权文献
信息查询
