Invention Grant
- Patent Title: Processes for producing NEP inhibitors or prodrugs thereof
- Patent Title (中): 制备NEP抑制剂或其前体药物的方法
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Application No.: US14076302Application Date: 2013-11-11
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Publication No.: US09061973B2Publication Date: 2015-06-23
- Inventor: David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
- Applicant: David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
- Applicant Address: US NJ East, Hanover
- Assignee: Novartis Pharmaceuticals Corporation
- Current Assignee: Novartis Pharmaceuticals Corporation
- Current Assignee Address: US NJ East, Hanover
- Agent David R. Kurlandsky
- Priority: EP08150353 20080117
- Main IPC: C07C271/22
- IPC: C07C271/22 ; C07D207/263 ; C07D207/36

Abstract:
The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
Public/Granted literature
- US20140243546A1 Processes Public/Granted day:2014-08-28
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