Invention Grant
- Patent Title: Mutations in the Bcr-Abl tyrosine kinase associated with resistance to STI-571
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Application No.: US13547954Application Date: 2012-07-12
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Publication No.: US09085644B2Publication Date: 2015-07-21
- Inventor: Charles L. Sawyers , Mercedes E. Gorre , Neil Pravin Shah , John Nicoll
- Applicant: Charles L. Sawyers , Mercedes E. Gorre , Neil Pravin Shah , John Nicoll
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Ropes & Gray LLP
- Agent James F. Haley, Jr.; Qianru Li
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C07K14/82 ; C12Q1/48
Abstract:
The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
Public/Granted literature
- US20120282622A1 MUTATIONS IN THE BCR-ABL TYROSINE KINASE ASSOCIATED WITH RESISTANCE TO STI-571 Public/Granted day:2012-11-08
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