Operating systems are described that interface applications and display screens capable of displaying two-dimensional and three-dimensional content. In one aspect, an operating system includes an application programming interface (API), a display driver interface, and a display driver. The API enables one or more applications to deliver requests that define a screen region and either a two-dimension indicator or a three-dimension indicator. The display driver interface passes configuration commands corresponding to the requests. The display driver is associated with a display screen. The display driver receives the configuration commands and responds by generating screen control signals to adjust the display screen to support the screen region.