Cytotoxic peptides and antibody drug conjugates thereof

Invention Grant

US09138486B2 Cytotoxic peptides and antibody drug conjugates thereof 有权

Title translation: 细胞毒性肽及其抗体药物偶联物

Patent Title: Cytotoxic peptides and antibody drug conjugates thereof
Patent Title (中): 细胞毒性肽及其抗体药物偶联物
Application No.: US14322262

Application Date: 2014-07-02
Publication No.: US09138486B2

Publication Date: 2015-09-22
Inventor: Matthew David Doroski , Andreas Maderna , Christopher John O'Donnell , Chakrapani Subramanyam , Beth Vetelino , Russell George Dushin , Pavel Strop , Edmund Idris Graziani
Applicant: PFIZER INC.
Applicant Address: US NY New York
Assignee: Pfizer Inc.
Current Assignee: Pfizer Inc.
Current Assignee Address: US NY New York
Agent David Rubin
Main IPC: A61K47/48
IPC: A61K47/48 ; A61K38/06 ; A61K38/08 ; A61K38/07 ; C07K7/02 ; C07K5/083 ; C07K5/02 ; C07K16/00

Abstract:

The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer.

Abstract(Chinese):

本发明涉及细胞毒性五肽，其抗体药物偶联物及其用于治疗癌症的方法。

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