发明授权
US09164086B2 Fluorescent dyes with phosphorylated hydroxymethyl groups and their use in light microscopy and imaging techniques
有权
具有磷酸化羟甲基的荧光染料及其在光学显微镜和成像技术中的应用
- 专利标题: Fluorescent dyes with phosphorylated hydroxymethyl groups and their use in light microscopy and imaging techniques
- 专利标题(中): 具有磷酸化羟甲基的荧光染料及其在光学显微镜和成像技术中的应用
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申请号: US13702252申请日: 2011-10-18
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公开(公告)号: US09164086B2公开(公告)日: 2015-10-20
- 发明人: Stefan W. Hell , Shamil Nizamov , Gerald Donnert , Kirill Kolmakov , Heiko Schill , Lars Kastrup , Christian A. Wurm , Vladimir N. Belov , Johanna Wildanger , Katrin Willig
- 申请人: Stefan W. Hell , Shamil Nizamov , Gerald Donnert , Kirill Kolmakov , Heiko Schill , Lars Kastrup , Christian A. Wurm , Vladimir N. Belov , Johanna Wildanger , Katrin Willig
- 申请人地址: DE Munich
- 专利权人: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
- 当前专利权人: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
- 当前专利权人地址: DE Munich
- 代理机构: Caesar Rivise, PC
- 国际申请: PCT/EP2011/005231 WO 20111018
- 国际公布: WO2013/056720 WO 20130425
- 主分类号: C09B57/02
- IPC分类号: C09B57/02 ; G01N33/52 ; C09B11/24 ; C09B57/10 ; G01N33/58 ; G01N33/533
摘要:
The invention relates to novel fluorescent dyes with phosphorylated hydroxymethyl groups, a method for preparing the same as well as to their use in imaging techniques. The fluorescent dyes are coumarin, rhodamine or BODIPY dyes having of one of the following general formulae I-III: wherein W=OP(O)Y1Y2 or P(O)Y1Y2, where Y1 and Y2 independently denote any of the following residues: OH, O(−), ORa and ORb, NHRa and NHRb, NRaRb and NRcRd, ORa and NHRb, ORa and NRbRc, NHRa and NRbRc; and any salt thereof.
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