Invention Grant
- Patent Title: Three-dimensional structure of isoprene synthase and its use thereof for generating variants
- Patent Title (中): 异戊二烯合酶的三维结构及其用于产生变体的用途
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Application No.: US13888265Application Date: 2013-05-06
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Publication No.: US09175313B2Publication Date: 2015-11-03
- Inventor: Zachary Q. Beck , Richard R. Bott , Jeffrey V. Miller , Christopher L. Rife , Derek H. Wells
- Applicant: Danisco US Inc. , The Goodyear Tire & Rubber Company
- Applicant Address: US CA Palo Alto US OH Akron
- Assignee: Danisco US Inc.,The Goodyear Tire & Rubber Company
- Current Assignee: Danisco US Inc.,The Goodyear Tire & Rubber Company
- Current Assignee Address: US CA Palo Alto US OH Akron
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Main IPC: C12N1/20
- IPC: C12N1/20 ; C12N1/00 ; C12N15/00 ; C12P7/04 ; C12P5/02 ; C12P5/00 ; C07H21/04 ; C12N9/88
Abstract:
The present invention provides a three-dimensional structures of P. tremuloides isoprene synthase and P. alba isoprene synthase. The invention also provides methods of using the three-dimensional structure to design isoprene synthases with improved activity for increased isoprene production in microbial host cells. Biosynthetically produced isoprene of the present invention finds use in the manufacture of rubber and elastomers.
Public/Granted literature
- US20130252303A1 THREE-DIMENSIONAL STRUCTURE OF ISOPRENE SYNTHASE AND ITS USE THEREOF FOR GENERATING VARIANTS Public/Granted day:2013-09-26
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