Invention Grant
- Patent Title: Long-acting human follicle-stimulating hormone formulation using immunoglobulin fragment
- Patent Title (中): 使用免疫球蛋白片段的长效人卵泡刺激素制剂
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Application No.: US13638860Application Date: 2011-04-04
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Publication No.: US09186415B2Publication Date: 2015-11-17
- Inventor: Chang Hwan Kim , Sung Kap Hong , Byung Sun Lee , Soo Young Kwak , Mi Ji Lee , In Young Choi , Se Chang Kwon
- Applicant: Chang Hwan Kim , Sung Kap Hong , Byung Sun Lee , Soo Young Kwak , Mi Ji Lee , In Young Choi , Se Chang Kwon
- Applicant Address: KR Hwaseong-si
- Assignee: HANMI SCIENCE CO., LTD
- Current Assignee: HANMI SCIENCE CO., LTD
- Current Assignee Address: KR Hwaseong-si
- Agency: Sughrue Mion, PLLC
- Priority: KR10-2010-0030574 20100402
- International Application: PCT/KR2011/002332 WO 20110404
- International Announcement: WO2011/122922 WO 20111006
- Main IPC: A61K38/24
- IPC: A61K38/24 ; A61K38/00 ; A61K38/16 ; C07K16/00 ; C07K1/00 ; A61K47/48
Abstract:
The present invention relates to a long-acting human follicle-stimulating hormone formulation having improved in vivo duration and stability, comprising a human follicle-stimulating hormone conjugate that is prepared by covalently linking human follicle-stimulating hormone with an immunoglobulin Fc region via a non-peptidyl polymer, and a preparation method thereof. The long-acting human follicle-stimulating hormone formulation of the present invention maintains in vivo activity of human follicle-stimulating hormone at a relatively high level and remarkably increases the serum half-life thereof.
Public/Granted literature
- US20130022626A1 LONG-ACTING HUMAN FOLLICLE-STIMULATING HORMONE FORMULATION USING IMMUNOGLOBULIN FRAGMENT Public/Granted day:2013-01-24
Information query
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