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1.发明授权Long-acting human follicle-stimulating hormone formulation using immunoglobulin fragment 有权使用免疫球蛋白片段的长效人卵泡刺激素制剂公开(公告)号：US09186415B2
公开(公告)日：2015-11-17
申请号：US13638860
申请日：2011-04-04
申请人： Chang Hwan Kim , Sung Kap Hong , Byung Sun Lee , Soo Young Kwak , Mi Ji Lee , In Young Choi , Se Chang Kwon
发明人： Chang Hwan Kim , Sung Kap Hong , Byung Sun Lee , Soo Young Kwak , Mi Ji Lee , In Young Choi , Se Chang Kwon
CPC分类号： A61K47/48215 , A61K47/60 , A61K47/68
摘要： The present invention relates to a long-acting human follicle-stimulating hormone formulation having improved in vivo duration and stability, comprising a human follicle-stimulating hormone conjugate that is prepared by covalently linking human follicle-stimulating hormone with an immunoglobulin Fc region via a non-peptidyl polymer, and a preparation method thereof. The long-acting human follicle-stimulating hormone formulation of the present invention maintains in vivo activity of human follicle-stimulating hormone at a relatively high level and remarkably increases the serum half-life thereof.
摘要翻译： 本发明涉及具有改善的体内持续时间和稳定性的长效促卵泡激素制剂，其包含人促卵泡激素缀合物，其通过非激素共价连接人卵泡刺激激素与免疫球蛋白Fc区而制备 - 肽基聚合物及其制备方法。 本发明的长效人促卵泡激素制剂在较高水平维持人卵泡刺激激素的体内活性，并且显着增加其血清半衰期。
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2.发明申请LONG-ACTING HUMAN FOLLICLE-STIMULATING HORMONE FORMULATION USING IMMUNOGLOBULIN FRAGMENT 有权使用免疫抑制蛋白片段长效人体激素激素配方公开(公告)号：US20130022626A1
公开(公告)日：2013-01-24
申请号：US13638860
申请日：2011-04-04
申请人： Chang Hwan Kim , Sung Kap Hong , Byung Sun Lee , Soo Young Kwak , Mi Ji Lee , In Young Choi , Se Chang Kwon
发明人： Chang Hwan Kim , Sung Kap Hong , Byung Sun Lee , Soo Young Kwak , Mi Ji Lee , In Young Choi , Se Chang Kwon
IPC分类号： C07K19/00 , A61P15/00 , A61P15/08 , C07K1/107 , A61K39/395
CPC分类号： A61K47/48215 , A61K47/60 , A61K47/68
摘要： The present invention relates to a long-acting human follicle-stimulating hormone formulation having improved in vivo duration and stability, comprising a human follicle-stimulating hormone conjugate that is prepared by covalently linking human follicle-stimulating hormone with an immunoglobulin Fc region via a non-peptidyl polymer, and a preparation method thereof. The long-acting human follicle-stimulating hormone formulation of the present invention maintains in vivo activity of human follicle-stimulating hormone at a relatively high level and remarkably increases the serum half-life thereof.
摘要翻译： 本发明涉及具有改善的体内持续时间和稳定性的长效促卵泡激素制剂，其包含人促卵泡激素缀合物，其通过非激素共价连接人卵泡刺激激素与免疫球蛋白Fc区而制备 - 肽基聚合物及其制备方法。 本发明的长效人促卵泡激素制剂在较高水平维持人卵泡刺激激素的体内活性，并且显着增加其血清半衰期。
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