A method for operating a driver assistance system of a vehicle combination is provided. The vehicle combination includes a tractor vehicle and at least one trailer, and the driver assistance system is designed to automatically actuate at least one element of the vehicle combination. The method comprises the following: At least a first parameter characterizing a potentially unstable driving condition of the trailer is detected. A determination is made as to whether an unstable driving condition of the trailer is imminent. If it is determined that an unstable driving condition of the trailer is imminent, a calculation is made of a position of the trailer and the at least one element is automatically actuated at a point in time when the trailer is positioned in the longitudinal direction of the tractor vehicle and directly in line behind the tractor vehicle.