Invention Grant
- Patent Title: TRPV4 antagonists
- Patent Title (中): TRPV4拮抗剂
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Application No.: US14125378Application Date: 2012-06-15
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Publication No.: US09187464B2Publication Date: 2015-11-17
- Inventor: Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Tram H. Hoang , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
- Applicant: Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Tram H. Hoang , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
- Applicant Address: GB Brentford, Middlesex
- Assignee: GlaxoSmithKline Intellectual Property (No. 2) Limited
- Current Assignee: GlaxoSmithKline Intellectual Property (No. 2) Limited
- Current Assignee Address: GB Brentford, Middlesex
- Agent Linda E. Hall; John E. Lemanowicz
- International Application: PCT/US2012/042622 WO 20120615
- International Announcement: WO2013/012500 WO 20130124
- Main IPC: C07D263/02
- IPC: C07D263/02 ; A61K31/423 ; C07D413/14 ; C07D417/14 ; C07D495/04 ; C07F9/6558 ; C07D419/14
Abstract:
The present invention relates to spirocarbamate compounds of Formula (I) in which R1, (R2)Y, R3, R4, X and A have the meanings given in the specification. The invention further provides pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and relates to their use of these compounds as TRPV4 antagonists in treating or preventing conditions associated with TRPV4 imbalance.
Public/Granted literature
- US20140121206A1 TRPV4 ANTAGONISTS Public/Granted day:2014-05-01
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