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公开(公告)号：US09187464B2
公开(公告)日：2015-11-17
申请号：US14125378
申请日：2012-06-15
申请人： Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Tram H. Hoang , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
发明人： Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Tram H. Hoang , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
IPC分类号： C07D263/02 , A61K31/423 , C07D413/14 , C07D417/14 , C07D495/04 , C07F9/6558 , C07D419/14
CPC分类号： C07D413/14 , C07D417/14 , C07D419/14 , C07D495/04 , C07F9/65583
摘要： The present invention relates to spirocarbamate compounds of Formula (I) in which R1, (R2)Y, R3, R4, X and A have the meanings given in the specification. The invention further provides pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and relates to their use of these compounds as TRPV4 antagonists in treating or preventing conditions associated with TRPV4 imbalance.
摘要翻译： 本发明涉及其中R1，（R2）Y，R3，R4，X和A具有本说明书中给出的含义的式（I）的螺氨酸甲酯化合物。 本发明还提供含有化合物或其药学上可接受的盐的药物组合物，并且涉及它们在治疗或预防与TRPV4不平衡相关的病症中作为TRPV4拮抗剂的用途。
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公开(公告)号：US20140121206A1
公开(公告)日：2014-05-01
申请号：US14125378
申请日：2012-06-15
申请人： Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Tram H. Hoang , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
发明人： Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Tram H. Hoang , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
IPC分类号： C07D413/14 , C07D495/04 , C07D417/14
CPC分类号： C07D413/14 , C07D417/14 , C07D419/14 , C07D495/04 , C07F9/65583
摘要： The present invention relates to spirocarbamate compounds of Formula (I) in which R1, (R2)Y, R3, R4, X and A have the meanings given in the specification. The invention further provides pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and relates to their use of these compounds as TRPV4 antagonists in treating or preventing conditions associated with TRPV4 imbalance.
摘要翻译： 本发明涉及其中R1，（R2）Y，R3，R4，X和A具有本说明书中给出的含义的式（I）的螺氨酸甲酯化合物。 本发明还提供含有化合物或其药学上可接受的盐的药物组合物，并且涉及它们在治疗或预防与TRPV4不平衡相关的病症中作为TRPV4拮抗剂的用途。
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公开(公告)号：US20140113916A1
公开(公告)日：2014-04-24
申请号：US14125370
申请日：2012-06-15
申请人： Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
发明人： Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
IPC分类号： C07D413/14 , C07D413/06
CPC分类号： C07D413/14 , C07D263/52 , C07D413/06 , C07D413/08
摘要： The present invention relates to spirocarbamate analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
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公开(公告)号：US09487507B2
公开(公告)日：2016-11-08
申请号：US14125370
申请日：2012-06-15
申请人： Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
发明人： Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
IPC分类号： A01N43/76 , A61K31/42 , C07D263/52 , C07D498/00 , C07D413/14 , C07D413/06 , C07D413/08
CPC分类号： C07D413/14 , C07D263/52 , C07D413/06 , C07D413/08
摘要： The present invention relates to spirocarbamate analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
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公开(公告)号：US08431590B2
公开(公告)日：2013-04-30
申请号：US12665335
申请日：2008-06-20
申请人： Brian W. Budzik , Hilary Schenck Eidam , Ryan Michael Fox , Krista B. Goodman , Dimitar B. Gotchev , Pamela A. Haile , Terry Vincent Hughes , Ronggang Liu , Nathan A. Miller , Tamara Ann Miskowski , Clark A. Sehon , Andrew Q. Viet , Gren Z. Wang , Jing Zhang
发明人： Brian W. Budzik , Hilary Schenck Eidam , Ryan Michael Fox , Krista B. Goodman , Dimitar B. Gotchev , Pamela A. Haile , Terry Vincent Hughes , Ronggang Liu , Nathan A. Miller , Tamara Ann Miskowski , Clark A. Sehon , Andrew Q. Viet , Gren Z. Wang , Jing Zhang
IPC分类号： C07D401/04 , C07D401/14 , A61K31/438 , A61K31/4439
CPC分类号： C07D471/10
摘要： The present invention relates to a compound of the following formula: where R1-R6, R10, Y, n, m, p, and q are as defined herein. Compounds and compositions of the present invention are useful for the treatment of diseases associated with the overexpression of CCR2.
摘要翻译： 本发明涉及下式的化合物：其中R 1 -R 6，R 10，Y，n，m，p和q如本文所定义。 本发明的化合物和组合物可用于治疗与过度表达CCR2相关的疾病。
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公开(公告)号：US20110034499A1
公开(公告)日：2011-02-10
申请号：US12665335
申请日：2008-06-20
申请人： Brian W. Budzik , Hilary Schenck Eidam , Ryan Michael Fox , Krista B. Goodman , Dimitar B. Gotchev , Pamela A. Haile , Terry Vincent Hughes , Ronggang Liu , Nathan A. Miller , Tamara Ann Miskowski , Clark A. Sehon , Andrew Q. Viet , Gren Z. Wang , Jing Zhang
发明人： Brian W. Budzik , Hilary Schenck Eidam , Ryan Michael Fox , Krista B. Goodman , Dimitar B. Gotchev , Pamela A. Haile , Terry Vincent Hughes , Ronggang Liu , Nathan A. Miller , Tamara Ann Miskowski , Clark A. Sehon , Andrew Q. Viet , Gren Z. Wang , Jing Zhang
IPC分类号： A61K31/438 , C07D471/10 , A61P9/10 , A61P29/00 , A61P31/16 , A61P3/00 , A61P3/10 , A61P25/00 , A61P11/06 , A61P13/12 , A61P9/04 , A61P25/28 , A61P1/00 , A61P15/00
CPC分类号： C07D471/10
摘要： The present invention relates to a compound of the following formula: where R1-R6, R10, Y, n, m, p, and q are as defined herein. Compounds and compositions of the present invention are useful for the treatment of diseases associated with the overexpression of CCR2.
摘要翻译： 本发明涉及下式的化合物：其中R 1 -R 6，R 10，Y，n，m，p和q如本文所定义。 本发明的化合物和组合物可用于治疗与过度表达CCR2相关的疾病。
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公开(公告)号：US08450484B2
公开(公告)日：2013-05-28
申请号：US13054834
申请日：2009-07-24
申请人： Michael Jonathan Bury , Mui Cheung , Hilary Schenck Eidam , Ryan Michael Fox , Krista Goodman , Eric Steven Manas
发明人： Michael Jonathan Bury , Mui Cheung , Hilary Schenck Eidam , Ryan Michael Fox , Krista Goodman , Eric Steven Manas
IPC分类号： C07D401/14 , C07D403/14
CPC分类号： A61K31/16 , A61K31/405 , C07D487/08
摘要： The present invention relates to diazabicyclo[2.2.1]hept-2-yl analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
摘要翻译： 本发明涉及二氮杂双环[2.2.1]庚-2-基类似物，含有它们的药物组合物及其作为TRPV4拮抗剂的用途。
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公开(公告)号：US20110130400A1
公开(公告)日：2011-06-02
申请号：US13054834
申请日：2009-07-24
申请人： Michael Jonathan Bury , Mui Cheung , Hilary Schenck Eidam , Ryan Michael Fox , Krista Goodman , Eric Steven Manas
发明人： Michael Jonathan Bury , Mui Cheung , Hilary Schenck Eidam , Ryan Michael Fox , Krista Goodman , Eric Steven Manas
IPC分类号： A61K31/5377 , C07D487/08 , A61K31/407 , A61P9/04 , A61P13/10 , A61P19/02 , A61K31/416 , A61K31/437 , A61K31/428 , A61K31/4439 , C07D471/04 , A61K31/422
CPC分类号： A61K31/16 , A61K31/405 , C07D487/08
摘要： The present invention relates to diazabicyclo[2.2.1]hept-2-yl analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
摘要翻译： 本发明涉及二氮杂双环[2.2.1]庚-2-基类似物，含有它们的药物组合物及其作为TRPV4拮抗剂的用途。
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公开(公告)号：US20080318990A1
公开(公告)日：2008-12-25
申请号：US12142899
申请日：2008-06-20
IPC分类号： A61K31/438 , C07D471/10 , A61P25/28 , A61P3/10
CPC分类号： C07D471/10
摘要： The present invention relates to a compound of the following formula: where R1-R6, R10, Y, n, m, p, and q are as defined herein. Compounds and compositions of the present invention are useful for the treatment of diseases associated with the overexpression of CCR2.
摘要翻译： 本发明涉及下式的化合物：其中R 1 -R 6，R 10，Y，n，m，p和q如本文所定义。 本发明的化合物和组合物可用于治疗与过度表达CCR2相关的疾病。
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公开(公告)号：US07723350B2
公开(公告)日：2010-05-25
申请号：US12142899
申请日：2008-06-20
IPC分类号： A61K31/438 , C07D471/10
CPC分类号： C07D471/10
摘要： The present invention relates to a compound of the following formula: where R1-R6, R10, Y, n, m, p, and q are as defined herein. Compounds and compositions of the present invention are useful for the treatment of diseases associated with the overexpression of CCR2.
摘要翻译： 本发明涉及下式的化合物：其中R 1 -R 6，R 10，Y，n，m，p和q如本文所定义。 本发明的化合物和组合物可用于治疗与过度表达CCR2相关的疾病。
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