The disclosure is directed to a system for managing data samples utilizing a time division multiplexing controller to allocate time slots for accessing a sample memory according to one or more modes of operation. The time division multiplexing controller is configured to allocate slots for concurrent access by a sample controller, a plurality of detectors, and a noise predictive calibrator when a normal mode is enabled. The time division multiplexing controller is further configured to allocate slots excluding at least one of the sample controller, the plurality of detectors, and the noise predictive calibrator from accessing the sample memory when a retry mode is enabled. In some embodiments, the time division multiplexing controller is further configured to allocate time slots for one or more clients other than the sample controller, the plurality of detectors, and the noise predictive calibrator.