发明授权
- 专利标题: Inhibitors of anaphase promoting complex activity
- 专利标题(中): 抑制剂后期促进复杂活动
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申请号: US13254235申请日: 2010-03-08
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公开(公告)号: US09205069B2公开(公告)日: 2015-12-08
- 发明人: Randall King , Xing Zeng , Shantanu Gaur
- 申请人: Randall King , Xing Zeng , Shantanu Gaur
- 申请人地址: US MA Cambridge
- 专利权人: President and Fellows of Harvard College
- 当前专利权人: President and Fellows of Harvard College
- 当前专利权人地址: US MA Cambridge
- 代理机构: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- 代理商 Ingrid A. Beattie
- 国际申请: PCT/US2010/026505 WO 20100308
- 国际公布: WO2010/102281 WO 20100910
- 主分类号: A61K31/155
- IPC分类号: A61K31/155 ; A61K31/18 ; A61K31/198
摘要:
The invention provides an anti-proliferative composition comprising a non-peptide analog of the C-terminal isoleucine-arginine (IR) tail motif of an activator of an anaphase promoting complex (APC). The invention further provides methods of inhibiting the ubiquitination activity of the APC by administering compositions of the invention.
公开/授权文献
- US20120115948A1 INHIBITORS OF ANAPHASE PROMOTING COMPLEX ACTIVITY 公开/授权日:2012-05-10