公开(公告)号：US09205069B2

公开(公告)日：2015-12-08

申请号：US13254235

申请日：2010-03-08

申请人： Randall King ,  Xing Zeng ,  Shantanu Gaur

发明人： Randall King ,  Xing Zeng ,  Shantanu Gaur

IPC分类号： A61K31/155 ,  A61K31/18 ,  A61K31/198

CPC分类号： A61K31/198 ,  A61K31/155 ,  A61K31/18

摘要： The invention provides an anti-proliferative composition comprising a non-peptide analog of the C-terminal isoleucine-arginine (IR) tail motif of an activator of an anaphase promoting complex (APC). The invention further provides methods of inhibiting the ubiquitination activity of the APC by administering compositions of the invention.

摘要翻译： 本发明提供一种抗增殖组合物，其包含后期促进复合物（APC）的活化剂的C末端异亮氨酸 - 精氨酸（IR）尾基序的非肽类似物。 本发明还提供了通过施用本发明的组合物来抑制APC泛素化活性的方法。

公开(公告)号：US20120115948A1

公开(公告)日：2012-05-10

申请号：US13254235

申请日：2010-03-08

申请人： Randall King ,  Xing Zeng ,  Shantanu Gaur

发明人： Randall King ,  Xing Zeng ,  Shantanu Gaur

IPC分类号： A61K31/24 ,  C12Q1/66 ,  A61P43/00 ,  C07C307/02

CPC分类号： A61K31/198 ,  A61K31/155 ,  A61K31/18

摘要： The invention provides an anti-proliferative composition comprising a non-peptide analog of the C-terminal isoleucine-arginine (IR) tail motif of an activator of an anaphase promoting complex (APC). The invention further provides methods of inhibing the ubiquitination activity of the APC by administering compositions of the invention.

摘要翻译： 本发明提供一种抗增殖组合物，其包含后期促进复合物（APC）的活化剂的C末端异亮氨酸 - 精氨酸（IR）尾基序的非肽类似物。 本发明还提供了通过施用本发明的组合物来抑制APC泛素化活性的方法。

公开(公告)号：US20130230458A1

公开(公告)日：2013-09-05

申请号：US13819957

申请日：2011-09-01

申请人： Randall King ,  Xing Zeng

发明人： Randall King ,  Xing Zeng

IPC分类号： A61K31/325 ,  A61K31/337 ,  A61K45/06 ,  A61K51/02

CPC分类号： A61K31/325 ,  A61K31/155 ,  A61K31/198 ,  A61K31/337 ,  A61K31/63 ,  A61K45/06 ,  A61K51/025

摘要： The invention provides compositions and methods for treating cell cycle disorders. Compositions of the invention include proTAME, a prodrug analog of TAME, and, optionally, one or more therapeutic agents.

摘要翻译： 本发明提供了治疗细胞周期障碍的组合物和方法。 本发明的组合物包括proTAME，TAME的前药类似物和任选的一种或多种治疗剂。

公开(公告)号：US20140070837A1

公开(公告)日：2014-03-13

申请号：US14082140

申请日：2013-11-16

申请人： Roger L. Jungerman ,  Randall King

发明人： Roger L. Jungerman ,  Randall King

IPC分类号： G01R31/26

CPC分类号： H02S50/10

摘要： A solar monitor measures electrical characteristics of a designated solar device within an array of solar devices that are coupled in series. The solar monitor includes a charge storage element and a charger coupled to the charge storage element to establish a positive voltage and/or a negative voltage on the charge storage element. A switch within the solar monitor is coupled in a shunt configuration with the designated solar device and with a subsequent device in the array. The switch selectively couples the charge storage element to the designated solar device to vary an operating current that flows between the designated solar device and the subsequent solar device. The solar monitor includes a current detector to measure the current of the designated solar device, and a voltage detector to measure the voltage of the designated solar device.

摘要翻译： 太阳能监视器测量串联耦合的太阳能装置阵列内的指定太阳能装置的电特性。 太阳能监视器包括电荷存储元件和耦合到电荷存储元件的充电器，以在电荷存储元件上建立正电压和/或负电压。 太阳能监视器内的开关以分配配置与指定的太阳能装置耦合，并且具有阵列中的后续装置。 开关选择性地将电荷存储元件耦合到指定的太阳能装置以改变在指定的太阳能装置和随后的太阳能装置之间流动的工作电流。 太阳能监视器包括用于测量指定的太阳能装置的电流的电流检测器和用于测量指定的太阳能装置的电压的电压检测器。

公开(公告)号：US07019746B2

公开(公告)日：2006-03-28

申请号：US10047733

申请日：2001-10-26

申请人： Karl Shubert ,  Randall King ,  Stanley E. Jaffe

发明人： Karl Shubert ,  Randall King ,  Stanley E. Jaffe

IPC分类号： G06T11/20

CPC分类号： G06T11/206 ,  G01J3/0264 ,  G01R13/02 ,  G01R13/029

摘要： Multiple signals are graphically presented. A signal for each measured frequency channel is separately represented on a display. Representations of the signals are superimposed. Center channel frequencies for all the representations of the signals are aligned relative to a single position on a first axis. Amplitude for all the representations of the signals is indicated relative to a second axis. Overlap of a signal within a compliance mask indicates violation of an amplitude minimum, an amplitude maximum or frequency drift.

公开(公告)号：US06637570B2

公开(公告)日：2003-10-28

申请号：US09997702

申请日：2001-11-29

申请人： John Miller ,  Randall King ,  Bryce Babcock

发明人： John Miller ,  Randall King ,  Bryce Babcock

IPC分类号： F16D4120

CPC分类号： F16D43/24 ,  F16D41/206 ,  F16H55/36

摘要： An over-running clutch pulley of the preferred embodiment includes a sheave member, a hub member located substantially concentrically within the sheave member, a sealing member, and a clutch member, which cooperate to rotationally engage the drive belt and the cylindrical shaft. The sheave member preferably includes a sheave input section adapted to engage the input device, a sheave clutch section defining a sheave clutch surface, and a sheave flange element. Similarly, the hub member preferably includes a hub output section adapted to engage the output device, a hub clutch section defining a hub clutch surface, and a hub lip element. The sealing member preferably includes a seal outer section frictionally engaged with the sheave flange element, and a seal inner section slidably engaged with the hub lip element. The sealing member preferably functions to substantially seal a cavity defined by the sheave flange element and the hub lip element.

摘要翻译： 优选实施例的超行走离合器滑轮包括滑轮构件，大致同心地设置在滑轮构件内的轮毂构件，密封构件和离合器构件，其配合以可旋转地接合驱动带和圆柱形轴。 滑轮构件优选地包括适于接合输入装置的滑轮输入部分，限定滑轮离合器表面的滑轮离合器部分和滑轮凸缘元件。 类似地，轮毂构件优选地包括适于接合输出装置的轮毂输出部分，限定轮毂离合器表面的轮毂离合器部分和轮毂唇缘元件。 密封构件优选地包括与滑轮凸缘元件摩擦接合的密封外部部分和与轮毂唇形元件可滑动地接合的密封件内部分。 密封构件优选用于基本上密封由滑轮法兰元件和轮毂唇缘元件限定的空腔。

公开(公告)号：US06564160B2

公开(公告)日：2003-05-13

申请号：US09887992

申请日：2001-06-22

申请人： Roger L. Jungerman ,  Lovell H. Camnitz ,  Randall King

发明人： Roger L. Jungerman ,  Lovell H. Camnitz ,  Randall King

IPC分类号： G01R3500

CPC分类号： G01R13/345

摘要： Repetitive sampling of a data signal is performed. A clock reference is generated. The clock reference has a known period relationship with the data signal. The clock reference and the data signal are simultaneously sampled. The sampled information from the clock reference is used to determine in what phase of the clock reference sampled values of the data signal occur.

公开(公告)号：US6071206A

公开(公告)日：2000-06-06

申请号：US79122

申请日：1998-05-14

申请人： Russell E. Monahan ,  Jonathan M. Adler ,  Randall King ,  Scott A. Wojan

发明人： Russell E. Monahan ,  Jonathan M. Adler ,  Randall King ,  Scott A. Wojan

IPC分类号： F02B67/06 ,  F16H15/56 ,  F16H55/36 ,  F16H55/49 ,  F16H15/00

CPC分类号： F16H15/56 ,  F16H2200/0034 ,  F16H55/49

摘要： A two speed pulley assembly comprised of a sheave, a brake member, an output member, and a brake. The sheave receives a rotational input and also includes a series of carrier arms which cooperate to define a circle which is coaxially with the sheave. Rollers are rotatably supported on said carrier arms. A braking member is rotatably supported relative to said sheave and includes portions defining a first raceway in contact with the rollers. An output sleeve is also rotationally supported relative to the sheave. The output sleeve includes portions defining a second raceway in contact with the rollers. The brake inhibits rotation of the braking member when engaged while permitting rotation thereof when disengaged. Mounted between the sheave and the output sleeve is a one-way clutch bearing. The clutch bearing engages when rotation of the sheave attempts to or begins to overrun rotation of the sleeve. During use, the sheave drives the output sleeve through the rollers at a rotational rate greater than that of the sheave when the brake is engaged. When the brake is disengaged, the sheave drives the output sleeve through the one-way clutch bearing at a one-to-one ratio. In this way the present invention provides two different driving speeds from a single belt pulley assembly thereby increasing the electrical output of an alternator at low engine speeds. Alternatively, the input and output member may be reversed to provide a speed reduction mechanism.

摘要翻译： 由滑轮，制动构件，输出构件和制动器构成的双速皮带轮组件。 滑轮接收旋转输入并且还包括一系列载体臂，其协作以限定与滑轮同轴的圆。 辊子可旋转地支撑在所述承载臂上。 制动构件相对于所述滑轮可旋转地支撑并且包括限定与滚子接触的第一滚道的部分。 输出套筒也相对于滑轮旋转地支撑。 输出套筒包括限定与辊接触的第二滚道的部分。 制动器在接合时禁止制动构件的旋转，同时在分离时允许制动构件的旋转。 安装在滑轮和输出套筒之间是单向离合器轴承。 离合器轴承在滑轮转动时尝试或开始超出套筒的旋转。 在使用期间，当制动器接合时，滑轮以大于滑轮的旋转速率通过滚子驱动输出套筒。 当制动器分离时，滑轮通过单向离合器轴承以一对一的比例驱动输出套筒。 以这种方式，本发明提供了来自单个带轮组件的两种不同的驱动速度，从而在低发动机速度下增加了交流发电机的电输出。 或者，输入和输出构件可以颠倒以提供减速机构。

公开(公告)号：US07686272B2

公开(公告)日：2010-03-30

申请号：US11820864

申请日：2007-06-20

申请人： Randall King

发明人： Randall King

IPC分类号： A47B97/04

CPC分类号： G09F7/20 ,  A47G1/12

摘要： An adjustable display holder is disclosed. One embodiment provides a display arm and a display base, wherein the display arm is pivotably connected to the base, and the arm and base have a tongue and groove arrangement, wherein the arm may be elastically deformed to connect to the base, and the arm may retain a shape that arranges the tongue and groove in a way that resists relative pivoting between the arm and base. In this manner, an adjustable display holder may be easily configured without compromising the utility of the display holder.

摘要翻译： 公开了一种可调显示器保持器。 一个实施例提供了显示臂和显示器基座，其中显示臂可枢转地连接到基座，并且臂和基座具有榫舌和凹槽布置，其中臂可以弹性变形以连接到基座，并且臂 可以保持以阻止臂和基座之间的相对枢转的方式布置舌部和凹槽的形状。 以这种方式，可以容易地构造可调节的显示器保持器，而不会影响显示器保持器的效用。

公开(公告)号：US20080315053A1

公开(公告)日：2008-12-25

申请号：US11820864

申请日：2007-06-20

申请人： Randall King

发明人： Randall King

IPC分类号： A47F5/10

CPC分类号： G09F7/20 ,  A47G1/12

摘要： An adjustable display holder is disclosed. One embodiment provides a display arm and a display base, wherein the display arm is pivotably connected to the base, and the arm and base have a tongue and groove arrangement, wherein the arm may be elastically deformed to connect to the base, and the arm may retain a shape that arranges the tongue and groove in a way that resists relative pivoting between the arm and base. In this manner, an adjustable display holder may be easily configured without compromising the utility of the display holder.

摘要翻译： 公开了一种可调显示器保持器。 一个实施例提供了显示臂和显示器基座，其中显示臂可枢转地连接到基座，并且臂和基座具有榫舌和凹槽布置，其中臂可以弹性变形以连接到基座，并且臂 可以保持以阻止臂和基座之间的相对枢转的方式布置舌部和凹槽的形状。 以这种方式，可以容易地构造可调节的显示器保持器，而不会影响显示器保持器的效用。