发明授权
US09221826B2 Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases
有权
吡咯并哒嗪JAK3抑制剂及其用于治疗炎症和自身免疫疾病的用途
- 专利标题： Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases
- 专利标题（中）： 吡咯并哒嗪JAK3抑制剂及其用于治疗炎症和自身免疫疾病的用途
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申请号： US14005572申请日： 2012-03-16
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公开(公告)号： US09221826B2公开(公告)日： 2015-12-29
- 发明人: Stephen T. Wrobleski , Jagabandhu Das , Lidia M. Doweyko , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Steven H. Spergel , John S. Tokarski , Hong Wu , Bingwei Vera Yang
- 申请人： Stephen T. Wrobleski , Jagabandhu Das , Lidia M. Doweyko , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Steven H. Spergel , John S. Tokarski , Hong Wu , Bingwei Vera Yang
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Princeton
- 国际申请： PCT/US2012/029337 WO 20120316
- 国际公布： WO2012/125887 WO 20120920
- 主分类号： A61K31/5025
- IPC分类号： A61K31/5025 ; A61K31/675 ; C07D487/04 ; C07F9/6561
摘要：
Disclosed are compounds of formula (I) and pharmaceutically acceptable salts thereof. The compounds of formula (I) inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.