Invention Grant
- Patent Title: Phenothiazine diaminium salts and their use
- Patent Title (中): 吩噻嗪二胺盐及其用途
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Application No.: US13984841Application Date: 2011-08-15
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Publication No.: US09283230B2Publication Date: 2016-03-15
- Inventor: Scott Clunas , John Mervyn David Storey , James Peter Sinclair , Thomas Craven Baddeley , Ahtsham Ishaq , Michael Simpson , Craig Williamson , Barry Alan Wood , Claude Michel Wischik , Charles Robert Harrington , Janet Elizabeth Rickard , David Horsley , Yin Sze Loh , Colin Marshall , Karrar Ahmad Khan
- Applicant: Scott Clunas , John Mervyn David Storey , James Peter Sinclair , Thomas Craven Baddeley , Ahtsham Ishaq , Michael Simpson , Craig Williamson , Barry Alan Wood , Claude Michel Wischik , Charles Robert Harrington , Janet Elizabeth Rickard , David Horsley , Yin Sze Loh , Colin Marshall , Karrar Ahmad Khan
- Applicant Address: SG Singapore
- Assignee: WisTa Laboratories Ltd.
- Current Assignee: WisTa Laboratories Ltd.
- Current Assignee Address: SG Singapore
- Agency: Foley & Lardner LLP
- Priority: SG201101060-0 20110211
- International Application: PCT/GB2011/001221 WO 20110815
- International Announcement: WO2012/107706 WO 20120816
- Main IPC: A61K31/5415
- IPC: A61K31/5415 ; C07D279/20 ; C07D309/04 ; C07C309/05 ; A61K9/20 ; C07C309/04 ; A61K9/28 ; C07C309/30 ; C07C309/35

Abstract:
The invention relates to compounds of general formula (I): wherein: each of R1 and R9 is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; and wherein: each of RA and RB is independently selected from: C1-4alkyl, halogenated C1-4alkyl, and C6-10aryl; or RA and RB are linked to form a group selected from: C1-6 alkylene and C6-10 arylene; and pharmaceutically acceptable salts thereof, which are useful in the treatment of, for example, Alzheimer's disease. In other aspects the invention also relates to novel formulations of 3,7-diamino-10H-phenothiazinium salts.
Public/Granted literature
- US20130315992A1 PHENOTHIAZINE DIAMINIUM SALTS AND THEIR USE Public/Granted day:2013-11-28
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