Invention Grant
US09289468B2 Fusion protein comprising circularly permuted form of trail/Apo2L, coding gene and use thereof
有权
融合蛋白包含循环形式的小鼠/ Apo2L，编码基因及其用途
- Patent Title: Fusion protein comprising circularly permuted form of trail/Apo2L, coding gene and use thereof
- Patent Title (中): 融合蛋白包含循环形式的小鼠/ Apo2L，编码基因及其用途
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Application No.: US14344289Application Date: 2011-09-16
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Publication No.: US09289468B2Publication Date: 2016-03-22
- Inventor: Shifang Yang , Junsheng Cui , Bing Zhu , Peng Wei
- Applicant: Shifang Yang , Junsheng Cui , Bing Zhu , Peng Wei
- Applicant Address: CN Beijing
- Assignee: Beijing Sunbio Biotech Co. Ltd.
- Current Assignee: Beijing Sunbio Biotech Co. Ltd.
- Current Assignee Address: CN Beijing
- Agency: Fitch, Even, Tabin & Flannery, LLP
- International Application: PCT/CN2011/001573 WO 20110916
- International Announcement: WO2013/037090 WO 20130321
- Main IPC: A61K38/16
- IPC: A61K38/16 ; A61K38/12 ; A61K38/00 ; A61P35/00 ; A61P35/02 ; C07K1/00 ; C07K14/00 ; C07K17/00 ; C07K16/00 ; C12N1/20 ; C12N15/00 ; A61K39/00 ; A61K39/385 ; A61K38/17 ; C07K14/715 ; C07K14/47 ; C07K14/525 ; C12N15/63 ; C12N15/62 ; C07K14/705 ; A61K45/06 ; C07K14/52
Abstract:
Provided is a fusion protein comprising circularly permuted form of TRAIL, and the fusion protein contains circularly permuted form of TRAIL and oligopeptides located at the N-terminus and/or C-terminus of the permuted form. The oligopeptides contain a repeating sequence consisting of 3-10 histidines. The components of the circularly permuted form of TRAIL from N-terminus to C-terminus are: (a) amino acids 135-281 of TRAIL, (b) a linker, and (c) amino acids 121-135 of TRAIL or amino acids 114-135 of TRAIL or amino acids 95-135 of TRAIL or any fragments of amino acids 95-135 of TRAIL containing amino acids 121-135 of TRAIL. Also provided is a method for treating cancer by using the fusion protein.
Public/Granted literature
- US20140342994A1 Fusion Protein Comprising Circularly Permuted Form Of Trail/Apo2L, Coding Gene And Use Thereof Public/Granted day:2014-11-20
Information query
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