Invention Grant
US09341625B2 Cell-surface signatures for isolating neurons from cell cultures derived from pluripotent stem cells
有权
从多能干细胞衍生的细胞培养物中分离神经元的细胞表面特征
- Patent Title: Cell-surface signatures for isolating neurons from cell cultures derived from pluripotent stem cells
- Patent Title (中): 从多能干细胞衍生的细胞培养物中分离神经元的细胞表面特征
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Application No.: US14381547Application Date: 2013-04-23
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Publication No.: US09341625B2Publication Date: 2016-05-17
- Inventor: Christian T. Carson , Jody Martin , Jason G. Vidal
- Applicant: Becton, Dickinson and Company
- Applicant Address: US NJ Franklin Lakes
- Assignee: Becton, Dickinson and Company
- Current Assignee: Becton, Dickinson and Company
- Current Assignee Address: US NJ Franklin Lakes
- Agency: Bozicevic, Field & Francis LLP
- Agent Bret E. Field
- International Application: PCT/US2013/037781 WO 20130423
- International Announcement: WO2013/173031 WO 20131121
- Main IPC: G01N33/569
- IPC: G01N33/569
Abstract:
The inventors disclose methods and systems that provide for the isolation and purification of neurons directly from heterogeneous cell cultures. The expression of various cell adhesion molecules was examined in pluripotent stem cells. Changes in the expression of one or more of these molecules correlates with the progression of cells from non-lineage committed to neural cells. Using one or more antibodies for these molecules in combination with antibodies specific for CD200 will enable one to identify and isolate neurons from a population cells.
Public/Granted literature
- US20150050667A1 Cell-Surface Signatures for Isolating Neurons from Cell Cultures Derived from Pluripotent Stem Cells Public/Granted day:2015-02-19
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