发明授权
US09353117B2 Substituted pyrazolopyrimidines as glucocerebrosidase activators
有权
取代的吡唑并嘧啶作为葡糖脑苷脂酶激活剂
- 专利标题: Substituted pyrazolopyrimidines as glucocerebrosidase activators
- 专利标题(中): 取代的吡唑并嘧啶作为葡糖脑苷脂酶激活剂
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申请号: US13991816申请日: 2011-12-08
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公开(公告)号: US09353117B2公开(公告)日: 2016-05-31
- 发明人: Juan Jose Marugan , Noel Southall , Ehud Goldin , Wei Zheng , Samarjit Patnaik , Ellen Sidransky , Omid Motabar , Wendy Westbroek
- 申请人: Juan Jose Marugan , Noel Southall , Ehud Goldin , Wei Zheng , Samarjit Patnaik , Ellen Sidransky , Omid Motabar , Wendy Westbroek
- 申请人地址: US DC Washington
- 专利权人: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES
- 当前专利权人: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES
- 当前专利权人地址: US DC Washington
- 代理机构: Cantor Colburn LLP
- 国际申请: PCT/US2011/063928 WO 20111208
- 国际公布: WO2012/078855 WO 20120614
- 主分类号: A61K31/519
- IPC分类号: A61K31/519 ; C07D487/04
摘要:
Substituted pyrazolopyrimidines and dihydropyrazolopyrimidines and related compounds, their methods of manufacture, compositions containing these compounds, and methods of use of these compounds in treating lysosomal storage disorders such as Gaucher disease are described herein. The compounds are of general Formula (I) in which variables R1-R7 and X are described in the application.
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